Nucleic Acids Research, 1994, Vol. 22, No. 11 2036-2041
© 1994
MOLECULAR BIOLOGY |
A novel growth-inducible gene that encodes a protein with a conserved cold-shock domain
Department of Biochemistry, Yamagata University School of Medicine lida-nishi, Yamagata 990-23 1Institute for Cell Biology and Genetics, Faculty of Agriculture, Iwate University Ueda, Morioka, Iwate 020, Japan
*To whom correspondence should be addressed
Received March 7, 1994. Revised April 22, 1994. Accepted April 22, 1994.
We have isolated a cDNA that encodes a novel member of the Y-box binding protein family, termed as RYB-a (Rat Y-box Binding protein-a). RYB-a is a 31 kDa protein that contains a conserved cold-shock domain and an amino acid alignment similar to those of charge zipper proteins. Expression of RYB-a mRNA was highly abundant in the skeletal muscle, spleen, and fetal liver. The expression is very low in new-born and adult livers, suggesting its expression is under developmental regulation. In addition, the expression of RYB-a mRNA was induced in the liver during regeneration and by stimulation of quiescent fibroblast cells with serum. Induction in the fibroblasts was inhibited by treating the cell with a specific tyrosine kinase inhibitor, genistein or by detachment of cell-adhesion. Since both treatments are known to inhibit G1 cells to enter S phase, RYB-a gene is thought to be a member of growth-inducible genes.
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