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Nucleic Acids Research, 1994, Vol. 22, No. 12 2264-2273
© 1994

MOLECULAR BIOLOGY

C-Myc binds to 5' flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation

Sabine Mai*, and Annika Jalava1

Basel Institute for Immunology Grenzacherstr. 487, CH-4005 Basel, Switzerland 1Centre for Biotechnology PO Box 123, SF-20521 Turku, Finland

*To whom correspondence should be addressed

Received March 28, 1994. Revised May 12, 1994. Accepted May 12, 1994.

The dihydrofolate reductase is a key enzyme of the folate metabolism which supplies the cell with dTTPs for DNA synthesis. Using cellular extracts, we demonstrate the formation of c-Myc/Max heterodimers at the dihydrofolate reductase (DHFR) 5' flanking CANNTG (E-box) motifs. The presence of these complexes correlates with c-Myc levels and active cellular proliferation.


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