Nucleic Acids Research, 1994, Vol. 22, No. 13 2552-2556
© 1994
RNA |
Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases
European Molecular Biology Laboratory Postfach 102209, Meyerhofstrasse 1, D69012 Heidelberg, Germany
*To whom correspondence should be addressed
Received March 31, 1994. Revised May 31, 1994. Accepted May 31, 1994.
Searches with dsRNA-binding domain profiles detected two copies of the domain in each of RNA helicase A, Drosophila maleless and C.elegans ORF T20G5_11 (of unknown function). RNA helicase A is unusual in being one of the few characterised DEAD/DExH helicases that are active as monomers. Other monomeric DEAD/DExH RNA helicases (p68, NPH-II) have domains that match another RNA-binding motif, the RGG repeat. The DEAD/DExH domain appears to be insufficient on its own to promote helicase activity and additional RNAbinding capacity must be supplied either as domains adjacent to the DEAD/DExH-box or by bound partners as in the elF-4AB dimer. The presence or absence of extra RNA-binding domains should allow classification of DEAD/DExH proteins as monomeric or multimeric helicases.
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
A. Vanden Wymelenberg, J. Gaskell, M. Mozuch, P. Kersten, G. Sabat, D. Martinez, and D. Cullen Transcriptome and Secretome Analyses of Phanerochaete chrysosporium Reveal Complex Patterns of Gene Expression Appl. Envir. Microbiol., June 15, 2009; 75(12): 4058 - 4068. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Izzo, C. Regnard, V. Morales, E. Kremmer, and P. B. Becker Structure-function analysis of the RNA helicase maleless Nucleic Acids Res., February 11, 2008; 36(3): 950 - 962. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Vanden Wymelenberg, G. Sabat, M. Mozuch, P. J. Kersten, D. Cullen, and R. A. Blanchette Structure, Organization, and Transcriptional Regulation of a Family of Copper Radical Oxidase Genes in the Lignin-Degrading Basidiomycete Phanerochaete chrysosporium. Appl. Envir. Microbiol., July 1, 2006; 72(7): 4871 - 4877. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. DeSousa, M. Mukhopadhyay, P. Pelka, X. Zhao, B. K. Dey, V. Robert, A. Pelisson, A. Bucheton, and A. R. Campos A Novel Double-stranded RNA-binding Protein, Disco Interacting Protein 1 (DIP1), Contributes to Cell Fate Decisions during Drosophila Development J. Biol. Chem., September 26, 2003; 278(39): 38040 - 38050. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. R. SAUNDERS and G. N. BARBER The dsRNA binding protein family: critical roles, diverse cellular functions FASEB J, June 1, 2003; 17(9): 961 - 983. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Zhou, K.-T. Choe, Z. Zaidi, Q. Wang, M. B. Mathews, and C.-G. Lee RNA helicase A interacts with dsDNA and topoisomerase II{alpha} Nucleic Acids Res., May 1, 2003; 31(9): 2253 - 2260. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. C. Ogilvie, B. J. Wilson, S. M. Nicol, N. A. Morrice, L. R. Saunders, G. N. Barber, and F. V. Fuller-Pace The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells Nucleic Acids Res., March 1, 2003; 31(5): 1470 - 1480. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. K. Levin and S. S. Patel Helicase from Hepatitis C Virus, Energetics of DNA Binding J. Biol. Chem., August 9, 2002; 277(33): 29377 - 29385. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Huang and Z.-R. Liu The ATPase, RNA Unwinding, and RNA Binding Activities of Recombinant p68 RNA Helicase J. Biol. Chem., April 5, 2002; 277(15): 12810 - 12815. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Zhang, K. Buder, C. Burkhardt, B. Schlott, M. Gorlach, and F. Grosse Nuclear DNA Helicase II/RNA Helicase A Binds to Filamentous Actin J. Biol. Chem., January 4, 2002; 277(1): 843 - 853. [Abstract] [Full Text] |
||||
![]() |
V. Robert, N. Prud'homme, A. Kim, A. Bucheton, and A. Pelisson Characterization of the flamenco Region of the Drosophila melanogaster Genome Genetics, June 1, 2001; 158(2): 701 - 713. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Sanjuán and I. Marín Tracing the Origin of the Compensasome: Evolutionary History of DEAH Helicase and MYST Acetyltransferase Gene Families Mol. Biol. Evol., March 1, 2001; 18(3): 330 - 343. [Abstract] [Full Text] |
||||
![]() |
Y. Wang, G. Duby, B. Purnelle, and M. Boutry Tobacco VDL Gene Encodes a Plastid DEAD Box RNA Helicase and Is Involved in Chloroplast Differentiation and Plant Morphogenesis PLANT CELL, November 1, 2000; 12(11): 2129 - 2142. [Abstract] [Full Text] |
||||
![]() |
Y. Takeda, P. Caudell, G. Grady, G. Wang, A. Suwa, G. C. Sharp, W. S. Dynan, and J. A. Hardin Human RNA Helicase A Is a Lupus Autoantigen That Is Cleaved During Apoptosis J. Immunol., December 1, 1999; 163(11): 6269 - 6274. [Abstract] [Full Text] [PDF] |
||||
![]() |
S Zhang, C Herrmann, and F Grosse Nucleolar localization of murine nuclear DNA helicase II (RNA helicase A) J. Cell Sci., January 8, 1999; 112(16): 2693 - 2703. [Abstract] [PDF] |
||||
![]() |
N. F. Vanzo, Y. S. Li, B. Py, E. Blum, C. F. Higgins, L. C. Raynal, H. M. Krisch, and A. J. Carpousis Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome Genes & Dev., September 1, 1998; 12(17): 2770 - 2781. [Abstract] [Full Text] |
||||
![]() |
H.-J. Liao, R. Kobayashi, and M. B. Mathews Activities of adenovirus virus-associated RNAs: Purification and characterization of RNA binding proteins PNAS, July 21, 1998; 95(15): 8514 - 8519. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Zhang and F. Grosse Domain Structure of Human Nuclear DNA Helicase II (RNA Helicase A) J. Biol. Chem., April 25, 1997; 272(17): 11487 - 11494. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. W. Carpick, V. Graziano, D. Schneider, R. K. Maitra, X. Lee, and B. R.G. Williams Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA J. Biol. Chem., April 4, 1997; 272(14): 9510 - 9516. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. L. Kelley and M. I. Kuroda Equality for X Chromosomes Science, December 8, 1995; 270(5242): 1607 - 1610. [Abstract] [PDF] |
||||
![]() |
S. Zhang, H. Maacke, and F. Grosse Molecular Cloning of the Gene Encoding Nuclear DNA Helicase II J. Biol. Chem., July 7, 1995; 270(27): 16422 - 16427. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Fujii, M. Okamoto, S. Aratani, T. Oishi, T. Ohshima, K. Taira, M. Baba, A. Fukamizu, and T. Nakajima A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1 J. Biol. Chem., February 16, 2001; 276(8): 5445 - 5451. [Abstract] [Full Text] [PDF] |
||||











