Skip Navigation

This Article
Right arrow Print PDF (7878K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (65)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Bowman, K. K.
Right arrow Articles by Freyer, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bowman, K. K.
Right arrow Articles by Freyer, G. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1994, Vol. 22, No. 15 3026-3032
© 1994

ENZYMOLOGY

A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6–4 photoproducts

Krista K. Bowman, Khalifah Sidik1, Colin A. Smith2, John-Stephen Taylor2, Paul W. Doetsch and Greg A. Freyer1,*

Departments of Biochemistry and Radiation Oncology, Emory University School of Medicine, Rollins Research Center Atlanta, GA 30322 1Center for Radiological Research, Columbia University College of Physicians and Surgeons 630 W. 168 Street, New York, NY 10032 2department of Chemistry, Washington University St Louis, MO 63130, USA

*To whom correspondence should be addressed

Received May 12, 1994. Revised July 6, 1994. We have discovered a new DNA endonuclease in the fission yeast Schizosaccharomyces pombe which recognizes cyclobutane pyrimidine dimers and (6–4) pyrimidine-pyrimidone photoproducts. S.pombe DNA endonuclease (SPDE) catalyzes a single ATPindependent incision immediately 5' to the UV photoproduct and generates termini containing 3' hydroxyl and 5' phosphoryl groups. Based on these properties, we propose that SPDE may function in a DNA repair capacity, representing the initial recognition/ cleavage step of a DNA excision repair pathway.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GENES CELLSHome page
S. Mochida and M. Yanagida
Distinct modes of DNA damage response in S. pombe G0 and vegetative cells
Genes Cells, January 1, 2006; 11(1): 13 - 27.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. M. Sheedy, D. Dimitrova, J. K. Rankin, K. L. Bass, K. M. Lee, C. Tapia-Alveal, S. H. Harvey, J. M. Murray, and M. J. O'Connell
Brc1-Mediated DNA Repair and Damage Tolerance
Genetics, October 1, 2005; 171(2): 457 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
M. Malik and J. L. Nitiss
DNA Repair Functions That Control Sensitivity to Topoisomerase-Targeting Drugs
Eukaryot. Cell, February 1, 2004; 3(1): 82 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
B. Ribar, T. Izumi, and S. Mitra
The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe
Nucleic Acids Res., January 2, 2004; 32(1): 115 - 126.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
A. M. Earl, S. K. Rankin, K.-P. Kim, O. N. Lamendola, and J. R. Battista
Genetic Evidence that the uvsE Gene Product of Deinococcus radiodurans R1 Is a UV Damage Endonuclease
J. Bacteriol., February 15, 2002; 184(4): 1003 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. L. Alleva and P. W. Doetsch
The nature of the 5'-terminus is a major determinant for DNA processing by Schizosaccharomyces pombe Rad2p, a FEN-1 family nuclease
Nucleic Acids Res., August 1, 2000; 28(15): 2893 - 2901.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Yasuhira, M. Morimyo, and A. Yasui
Transcription Dependence and the Roles of Two Excision Repair Pathways for UV Damage in Fission Yeast Schizosaccharomyces pombe
J. Biol. Chem., September 17, 1999; 274(38): 26822 - 26827.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Kaur, J. L. A. Fraser, G. A. Freyer, S. Davey, and P. W. Doetsch
A Uve1p-Mediated Mismatch Repair Pathway in Schizosaccharomyces pombe
Mol. Cell. Biol., July 1, 1999; 19(7): 4703 - 4710.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. Muris, K Vreeken, A. Carr, J. Murray, C Smit, P. Lohman, and A Pastink
Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity
J. Cell Sci., January 1, 1996; 109(1): 73 - 81.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
S. Okano, S.-i. Kanno, S. Nakajima, and A. Yasui
Cellular Responses and Repair of Single-strand Breaks Introduced by UV Damage Endonuclease in Mammalian Cells
J. Biol. Chem., October 13, 2000; 275(42): 32635 - 32641.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.