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Nucleic Acids Research, 1994, Vol. 22, No. 15 3151-3154
© 1994


MOLECULAR BIOLOGY

LRG1 is expressed during speculation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains

Liz Müller*, Gang Xu1, Richard Wells2, Cornelis P. Hollenberg1 and Wolfgang Piepersberg3

German Cancer Research Center Im Neuenheimer Feld 280, 69120 Heidelberg 1Institute of Microbiology, University of Dusseldorf 40225 Dusseldorf, Germany 2department of Biological Sciences, USC Los Angeles Los Angeles, CA 90089-0371, USA 3department of Microbiology, University of Wuppertal 42097 Wuppertal, Germany

*To whom correspondence should be addressed

Received March 31, 1994. Revised June 29, 1994. Accepted June 29, 1994.

We here report the sequence of a yeast gene LRG1 whose deduced amino acid sequence contains sequence motifs similar to LIM domain proteins in the amino-terminal, and to rho/rac GTPase activating proteins (rho/racGAP's) in the carboxy-terminal part. LRG1 expression is differentially regulated showing a peak of expression in sporulating cells. Gene disruption experiments indicate that the gene is not essential and may play a role during mating.


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