Nucleic Acids Research, 1994, Vol. 22, No. 18 3685-3688
© 1994
MOLECULAR BIOLOGY |
Expression cloning in K$ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator
Institut de Pharmacologie Moléculaire et Cellulaire CNRS UPR411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne 1Centre de Biochimie, CNRS UMR134, Université de Nice Sophia Antipolis, Faculté des Sciences Parc Valrose, 06108 Nice Cedex, France
*To whom correspondence should be addressed
Received June 27, 1994. Revised August 10, 1994. Accepted August 10, 1994.
The rat HBP1 cDNA was cloned by its capacity to suppress the potassium transport-defective phenotype of mutant Saccharomyces cerevisiae cells. HBP1 cDNA encodes a 513 amino acids protein which, unexpectedly, does not share any homology with K$ transporters or K$ channels. However, a search in protein databases reveals that HBP1 contains a putative DNA-binding domain called HMG-box. Northern blot analysis shows that HBP1 is expressed in a variety of tissues and that in adipocyte and myogenic cell lines, its expression is directly related to differentiation. Taken together, the results suggest that the rat HBP1 is a new member of the HMG class of transcriptional regulators involved in cell differentiation pathways.
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