Nucleic Acids Research, 1994, Vol. 22, No. 18 3715-3721
© 1994
MOLECULAR BIOLOGY |
The DNA polymerase genes of several HMU-bacteriophages have similar group I introns with highly divergent open reading frames
Department of Biological Sciences, Center for Molecular Genetics, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
*To whom correspondence should be addressed
Received June 6, 1994. Revised July 25, 1994. Accepted July 25, 1994.
A previous report described the discovery of a group I, self-splicing intron in the DNA polymerase gene of the Bacillus subtilis bacteriophage SPO1 (1). In this study, the DNA polymerase genes of three close relatives of SPO1: SP82, 2C and øe, were also found to be interrupted by an intron. All of these introns have group I secondary structures that are extremely similar to one another in primary sequence. Each is interrupted by an open reading frame (ORF) that, unlike the intron core or exon sequences, are highly diverged. Unlike the relatives of Escherichia coli bacteriophage T4, most of which do not have introns (2), this intron seems to be common among the relatives of SPO1.
$ Present address: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
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