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Nucleic Acids Research, 1994, Vol. 22, No. 18 3728-3736
© 1994

MOLECULAR BIOLOGY

Cloning and molecular characterization of a novel chromosome specific centromere sequence of Chinese hamster

Károly Fátyol*, Imre Cserpán, Tünde Praznovszky, Judit Kereso and Gyula Hadlaczky

Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences H-6701 Szeged, PO Box 521, Hungary

*To whom correspondence should be addressed

Revised July 25, 1994. Accepted July 25, 1994.

We isolated and characterized the first chromosomespecific satellite DNA (HC2sat) of Chinese hamster. This novel satellite was localized to the pericentric region of hamster chromosome 2. The 2.8 kb long repeat unit of HC2sat was identified and two such units were sequenced. Extended shortrange periodicity could not be revealed in repeat units. These elements are amongst the largest satellite repeat units reported from mammals to date. HC2sat is a major constituent of the pericentric region of CHO chromosome 2 representing a 7 – 14 Mb long DNA segment. Studies of long range organization of HC2sat indicated that the formation of the satellite array might occur in different phases and involved different amplification mechanisms.


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