Skip Navigation

This Article
Right arrow Print PDF (1663K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Muyldermans, S.
Right arrow Articles by Travers, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muyldermans, S.
Right arrow Articles by Travers, A. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1994, Vol. 22, No. 25 5635-5639
© 1994

Articles

Differential association of linker histones H1 and H5 with telomeric nucleosomes in chicken erythrocytes

Serge Muyldermans*,, Jan De Jonge, Lode Wyns and Andrew A. Travers1

Vrije Universiteit Brussel, Instituut voor Moleculaire Biologie Paardenstraat 65, B-1640 Sint Genesius Rode, Belgium 1MRC Laboratory for Molecular Biology Hills Road, Cambridge CB2 2QH, UK

*To whom correspondence should be addressed

Received September 5, 1994. Revised September 11, 1994. Accepted September 11, 1994.

Rat liver telomeric DNA Is organised Into nucleosomes characterised by a shorter and more homogeneous average nucleosomal repeat than bulk chromatin as shown by Makarov et al. (1). The latter authors were unable to detect the association of any linker hlstone with the telomeric DNA. We have confirmed these observations but show that in sharp contrast chicken erythrocyte telomeric DNA Is organised Into nucleosomes whose spacing length and heterogeneity are Indistinguishable from those of bulk chromatin. We further show that chicken erythrocyte telomeric chromatin contains chromatosomes which are preferentially associated with hlstone H1 relative to hlstone H5. This contrasts with bulk chromatin where hlstone H5 Is the more abundant species. This observation strongly suggests that telomeric DNA condensed into nucleosome core particles has a higher affinity for H1 than H5. We discuss the origin of the discrimination of the lysine rich histones in terms of DNA sequence preferences, telomere nucleosome preferences and particular constraints of the higher order chromatin structure of telomeres.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
D J Wallace, E-M Salonen, E Avaniss-Aghajani, R Morris, A L Metzger, and N Pashinian
Anti-telomere antibodies in systemic lupus erythematosus: a new ELISA test for anti-DNA with potential pathogenetic implications
Lupus, June 1, 2000; 9(5): 328 - 332.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
J. K. Bedoyan, S. Lejnine, V. L. Makarov, and J. P. Langmore
Condensation of Rat Telomere-specific Nucleosomal Arrays Containing Unusually Short DNA Repeats and Histone H1
J. Biol. Chem., August 2, 1996; 271(31): 18485 - 18493.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.