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Nucleic Acids Research, 1994, Vol. 22, No. 3 485-491
© 1994

MOLECULAR BIOLOGY

Intramolecular recombination in polymavirus DNA is controlled by promoter elements

Chantal Nault, Stéphane Veilleux, Louis Delbecchi, Danielle Bourgaux-Ramoisy and Pierre Bourgaux*

Department of Microbiology, Faculty of Medicine, Université de Sherbrooke Sherbrooke, Québec J1H 5N4, Canada

*To whom correspondence should be addressed

Received August 20, 1993. Revised December 22, 1993. Accepted December 22, 1993.

We show here that Intramolecular homologous recombination in polyomavirus (Py) DNA depends upon discrete sequence elements of the viral regulatory region which are believed to regulate transcription initiation and exert little or no cls-control over replication. Either deleting the viral early promoter (EP) or inverting the viral late promoter (LP) strongly impairs viral DNA recombination under conditions allowing viral DNA replication to proceed undisturbed. These findings suggest that bi-directional transcription proceeding from the intergenic region favors intramolecular recombination.


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