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Nucleic Acids Research, 1994, Vol. 22, No. 6 1075-1078
© 1994

MOLECULAR BIOLOGY

Detection of deletions in the mitochondrial genome of Caenorhabditis elegans

Simon Melov1,*, Gerald Z. Hertz2, Gary D. Stormo2 and Thomas E. Johnson1,3

1Institute for Behavioral Genetics Boulder, CO 80309, USA 2Department of Molecular, Cellular, and Developmental Biology Boulder, CO 80309, USA 3Department of Psychology, University of Colorado Boulder, CO 80309, USA

*To whom correspondence should be addressed

Received December 28, 1993. Revised February 15, 1994. Accepted February 15, 1994.

We have examined an aging population of Caenorhabditis elegans via a PCR assay to determine if deletions in the mitochondrial genome occur in the nematode. We detected eight such deletions, identified the breakpoints of four of these, and discovered direct repeats of 4–8 base pairs at the site of all four deletions. Six of the eight repeats involved in the deletions are located in or immediately adjacent to tRNAs. Without a biochemical bias, the probability of direct repeats being present at all four breakpoints was 4x10–6.


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