Nucleic Acids Research, 1994, Vol. 22, No. 7 1147-1154
© 1994
MOLECULAR BIOLOGY |
The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed
INSERM U301 and SDI no. 16954 I CNRS, Institut de Génétique Moléculaire 27 rue Juliette Dodu, 75010 Paris 1Laboratoire d'lmmunopathologie, Université Paris VII, Institut d'Hématologie, Hôpital Saint Louis Paris, France
*To whom correspondence should be addressed
Received January 18, 1994. Revised March 7, 1994. Accepted March 7, 1994.
In a previous study of a t(4;16)(q26;p13) translocatlon, found in a human malignant T-cell lymphoma the BCMA gene, located on chromosome band 16p13.1, has been characterized. In this study we show that the BCMA gene is organized into three exons and its major initiation transcription site is located 69 nucleotldes downstream of a TATA box. RNase protection assays demonstrated that the BCMA gene is preferentially expressed in mature B cells, suggesting a role for this gene in the B-cell developmental process. A cDNA complementary to the BCMA cDNA was cloned and sequenced and its presence was assessed by RNase protection assay and anchor-PCR amplification. This antlsense-BCMA RNA is transcribed from the same locus as BCMA, and exhibits mRNA characteristic features, e.g. polyadenylation and splicing. It also contains an ORF encoding a putative 115 aa polypeptlde, presenting no homology with already known sequences. RNase protection assays demonstrated the simultaneous expression of natural sense and antisense-BCMA transcripts In the majority of human B-cell lines tested.
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