Nucleic Acids Research, 1995, Vol. 23, No. 10 1758-1765
© 1995
MOLECULAR BIOLOGY |
Cell stress and translational inhibitors transiently increase the abundance of mammalian SINE transcripts
1Section of Molecular and Cellular Biology USA 2Department of Entomology and Antibody Engineering Laboratory USA 3Department of Chemistry, University of California Davis, CA 95616, USA
* To whom correspondence should be addressed at Section of Molecular and Cellular Biology, 149 Bnggs Hall, University of California, Davis, CA 95616, USA
Received January 24, 1995. Revised April 3, 1995. Accepted April 3, 1995.
The abundance of Alu RNA is transiently increased by heat shock in human cell lines. This effect Is specific to Alu repeats among Pol III transcribed genes, since the abundance of 7SL, 7SK, 5S and U6 RNAs is essentially unaffected by heat shock. The rapid Induction of Alu expression precedes the heat shock induction of mRNAs for the ubiquitin and HSP 70 heat shock genes. Heat shock mimetics also transiently induce Alu expression indicating that increased Alu expression Is a general cell-stress response. Cyclo-heximide treatment rapidly and transiently increases the abundance of Alu RNA. Again, compared with other genes transcribed by Pol III, this increase is specific to Alu. However, as distinguished from the cell stress response, cycloheximlde does not Induce expression of HSP 70 and ublqultln mRNAs. Puromy-cin also increases Alu expression, suggesting that this response is generally caused by translational inhibition. The response of mammalian SINEs to cell stress and translational inhibition is not limited to SINEs which are Alu homologues. Heat shock and cyclohexi-mide each transiently induce Pol III directed expression of B1 and B2 RNAs in mouse cells and C-element RNA in rabbit cells. Together, these three species exemplify the known SINE composition of placental mammals, suggesting that mammalian SINEs are similarly regulated and may serve a common function.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Mourier and E. Willerslev Retrotransposons and non-protein coding RNAs Brief Funct Genomic Proteomic, November 1, 2009; 8(6): 493 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Bortolin-Cavaille, M. Dance, M. Weber, and J. Cavaille C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts Nucleic Acids Res., June 1, 2009; 37(10): 3464 - 3473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Yakovchuk, J. A. Goodrich, and J. F. Kugel B2 RNA and Alu RNA repress transcription by disrupting contacts between RNA polymerase II and promoter DNA within assembled complexes PNAS, April 7, 2009; 106(14): 5569 - 5574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P. Belancio, D. J. Hedges, and P. Deininger Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health Genome Res., March 1, 2008; 18(3): 343 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Muotri, M. C.N. Marchetto, N. G. Coufal, and F. H. Gage The necessary junk: new functions for transposable elements Hum. Mol. Genet., October 15, 2007; 16(R2): R159 - R167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Espinoza, J. A. Goodrich, and J. F. Kugel Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription RNA, April 1, 2007; 13(4): 583 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Herceg Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors Mutagenesis, March 1, 2007; 22(2): 91 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. V. Prasanth and D. L. Spector Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum Genes & Dev., January 1, 2007; 21(1): 11 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hasler and K. Strub Alu elements as regulators of gene expression Nucleic Acids Res., November 14, 2006; 34(19): 5491 - 5497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jolly and S. C. Lakhotia Human sat III and Drosophila hsr{omega} transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells Nucleic Acids Res., November 14, 2006; 34(19): 5508 - 5514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Iwashita, S. Ueno, K. Nakashima, S.-Y. Song, K. Ohshima, K. Tanaka, H. Endo, J. Kimura, M. Kurohmaru, K. Fukuta, et al. A Tandem Gene Duplication Followed by Recruitment of a Retrotransposon Created the Paralogous Bucentaur Gene (bcntp97) in the Ancestral Ruminant Mol. Biol. Evol., April 1, 2006; 23(4): 798 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Farkash, G. D. Kao, S. R. Horman, and E. T. L. Prak Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay Nucleic Acids Res., February 28, 2006; 34(4): 1196 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hasler and K. Strub Alu RNP and Alu RNA regulate translation initiation in vitro. Nucleic Acids Res., January 1, 2006; 34(8): 2374 - 2385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B S Nunez, P M Piermarini, A N Evans, and S L Applebaum Cloning and characterization of cDNAs encoding steroidogenic acute regulatory protein from freshwater stingrays (Potamotrygon spp.) J. Mol. Endocrinol., December 1, 2005; 35(3): 557 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Schutz, H. B. Urnovitz, L. Iakoubov, W. Schulz-Schaeffer, W. Wemheuer, and B. Brenig Bov-tA Short Interspersed Nucleotide Element Sequences in Circulating Nucleic Acids from Sera of Cattle with Bovine Spongiform Encephalopathy (BSE) and Sera of Cattle Exposed to BSE Clin. Vaccine Immunol., July 1, 2005; 12(7): 814 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Sonkoly, Z. Bata-Csorgo, A. Pivarcsi, H. Polyanka, A. Kenderessy-Szabo, G. Molnar, K. Szentpali, L. Bari, K. Megyeri, Y. Mandi, et al. Identification and Characterization of a Novel, Psoriasis Susceptibility-related Noncoding RNA gene, PRINS J. Biol. Chem., June 24, 2005; 280(25): 24159 - 24167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pelissier, C. Bousquet-Antonelli, L. Lavie, and J.-M. Deragon Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana Nucleic Acids Res., July 28, 2004; 32(13): 3957 - 3966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jolly, A. Metz, J. Govin, M. Vigneron, B. M. Turner, S. Khochbin, and C. Vourc'h Stress-induced transcription of satellite III repeats J. Cell Biol., January 5, 2004; 164(1): 25 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-R. Zhou, A. S. Lau, and J. J. Pestka Role of Double-Stranded RNA-Activated Protein Kinase R (PKR) in Deoxynivalenol-Induced Ribotoxic Stress Response Toxicol. Sci., August 1, 2003; 74(2): 335 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Morales, E. T. Snow, and J. P. Murnane Environmental factors affecting transcription of the human L1 retrotransposon. II. Stressors Mutagenesis, March 1, 2003; 18(2): 151 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Sonna, J. Fujita, S. L. Gaffin, and C. M. Lilly Molecular Biology of Thermoregulation: Invited Review: Effects of heat and cold stress on mammalian gene expression J Appl Physiol, April 1, 2002; 92(4): 1725 - 1742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bird DNA methylation patterns and epigenetic memory Genes & Dev., January 1, 2002; 16(1): 6 - 21. [Full Text] [PDF]
|
|
|
|
|
|
R. O. Stuart, K. T. Bush, and S. K. Nigam Changes in global gene expression patterns during development and maturation of the rat kidney PNAS, April 25, 2001; (2001) 91110798. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Liang, H. Igarashi, T. Tsuzuki, Y. Nakabeppu, M. Sekiguchi, K. S. Kasprzak, and Y.-H. Shiao Presence of Potential Nickel-Responsive Element(s) in the Mouse MTH1 Promoter Ann. Clin. Lab. Sci., January 1, 2001; 31(1): 91 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Li, C. Kim, C. M. Rubin, and C. W. Schmid K562 cells implicate increased chromatin accessibility in Alu transcriptional activation Nucleic Acids Res., August 15, 2000; 28(16): 3031 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Arnaud, C. Goubely, T. Pélissier, and J.-M. Deragon SINE Retroposons Can Be Used In Vivo as Nucleation Centers for De Novo Methylation Mol. Cell. Biol., May 15, 2000; 20(10): 3434 - 3441. [Abstract] [Full Text]
|
|
|
|
|
|
X. Liu, J. A. Clemens, T. Yin, D. T. Stephenson, E. M. Johnstone, Y. Du, J. A. Panetta, S. M. Paul, and S. P. Little Rat B2 Sequences Are Induced in the Hippocampal CA1 Region After Transient Global Cerebral Ischemia J. Biol. Chem., October 1, 1999; 274(40): 28674 - 28681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Kaufman Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls Genes & Dev., May 15, 1999; 13(10): 1211 - 1233. [Full Text]
|
|
|
|
|
|
H. B. Urnovitz, J. J. Tuite, J. M. Higashida, and W. H. Murphy RNAs in the Sera of Persian Gulf War Veterans Have Segments Homologous to Chromosome 22q11.2 Clin. Vaccine Immunol., May 1, 1999; 6(3): 330 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Goodier and R. J. Maraia Terminator-specific Recycling of a B1-Alu Transcription Complex by RNA Polymerase III Is Mediated by the RNA Terminus-binding Protein La J. Biol. Chem., October 2, 1998; 273(40): 26110 - 26116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tretiakova, G. L. Gallia, N. Shcherbik, B. Jameson, E. M. Johnson, S. Amini, and K. Khalili Association of Puralpha with RNAs Homologous to 7 SL Determines Its Binding Ability to the Myelin Basic Protein Promoter DNA Sequence J. Biol. Chem., August 28, 1998; 273(35): 22241 - 22247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-M. Chu, R. Ballard, B. W. Carpick, B. R. G. Williams, and C. W. Schmid Potential Alu Function: Regulation of the Activity of Double-Stranded RNA-Activated Kinase PKR Mol. Cell. Biol., January 1, 1998; 18(1): 58 - 68. [Abstract] [Full Text]
|
|
|
|
|
|
E. W. Englander and B. H. Howard A Naturally Occurring T(14)A[IMAGE] Tract Blocks Nucleosome Formation Over the Human Neurofibromatosis Type 1 (NF1)-Alu Element J. Biol. Chem., March 8, 1996; 271(10): 5819 - 5823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Bovia and K Strub The signal recognition particle and related small cytoplasmic ribonucleoprotein particles J. Cell Sci., January 11, 1996; 109(11): 2601 - 2608. [Abstract] [PDF]
|
|
|
|
|
|
Y. Ueda and G. Chaudhuri Differential Expression of B1-containing Transcripts in Leishmania-exposed Macrophages J. Biol. Chem., June 16, 2000; 275(25): 19428 - 19432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. O. Stuart, K. T. Bush, and S. K. Nigam Changes in global gene expression patterns during development and maturation of the rat kidney PNAS, May 8, 2001; 98(10): 5649 - 5654. [Abstract] [Full Text] [PDF]
|
|