Nucleic Acids Research, 1995, Vol. 23, No. 12 2083-2091
© 1995
SURVEY AND SUMMARY |
Stereochemical basis of DNA bending by transcription factors
MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK 1Tohoku University, School of Medicine, Seiryo-machi Sendai, 980-77, Japan
* To whom correspondence should be addressed
Received April 24, 1995. Accepted May 11, 1995.
Superstructure-formation of DNA plays an Important role In transcription regulation as well as In chromatln formation. To understand the stereochemical basis of DNA bending by proteins we analysed the structural characteristics of dinucleotide steps which occur at the site where DNA is bent upon binding a transcription factor. When DNA is considerably bent in a crystal structure the bending is not spread smoothly over a length, but the DNA is kinked at a pair of crucial steps which are highly rolled and untwisted. These rolled steps are spaced 6–10 bp apart and are predominantly occupied by pyrimidine-purine sequences. In association with another dinucleotide step at the centre, which combines 6 bp-spaced rolled steps towards the same side of the DNA, these produce two essentially different types of DNA bending.
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