Nucleic Acids Research, 1995, Vol. 23, No. 12 2127-2136
© 1995
MOLECULAR BIOLOGY |
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
Amgen Institute, Ontario Cancer Institute and Departments of Immunology and Medical Biophysics University of Toronto, 500 Sherbourne Street, Toronto, Ontario M4X 1K9, Canada 1Institute for Molecular and Cellular Biology Osaka University, Yamada-oka 1-3, Suita-shi, Osaka 565, Japan 2Amgen Inc., Amgen Center 1840 Dehavilland Drive, Thousand Oaks, CA 91320-1789, USA
* To whom correspondence should be addressed
Received March 27, 1995. Revised May 8, 1995. Accepted May 8, 1995.
Interferon regulatory factor (IRF) genes encode a family of DNA-blndlng proteins that are involved in the transcriptional regulation of type-l Interferon and/or interferon-inducible genes. We report here the characterization of LSIRF, a new member of the IRF gene family cloned from mouse spleen by the polymerase chain reaction using degenerate primers. LSIRF was found to encode a 51 kDa protein that shares a high degree of amino acid sequence homology in the DNA-binding domain with other IRF family members. LSIRF expression was detectable only In lymphold cells. In contrast to other IRF genes, LSIRF expresslon was not Induced by interferons, but rather by antigen-receptor mediated stimuli such as plant lectins, CD3 or IgM crosslinking. In In vitro DNA binding studies, LSIRF was able to bind to the interferon-stimulated response element (ISRE) of the MHC class I promoter. The expression pattern and DNA binding activities suggest that LSIRF plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
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