Nucleic Acids Research, 1995, Vol. 23, No. 17 3365-3372
© 1995
MOLECULAR BIOLOGY |
The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research Fulham Road, London SW3 6JB, UK 1Center for Molecular and Cellular Biology, The University of Queensland Brisbane, Queensland 4072, Australia 2Department of Anatomical Sciences, The University of Queensland Brisbane, Queensland 4072, Australia
*To whom correspondence should be addressed
Received July 3, 1995. Revised August 2, 1995. Accepted August 2, 1995.
We have cloned and sequenced a full-length cDNA for the HMG box-containing, SRY-related gene Sox6 from mouse., The deduced protein sequence of Sox6 has considerable homology with that of the previously determined Sox5 sequence. It seems likely that these genes have diverged more recently than other members of the SOX gene family, although the two genes map to different chromosomes in the mouse. In common with Sox5, Sox6 is highly expressed in the adult mouse testis and the HMG domains of both proteins bind to the sequence 5'-AACAAT-3'. This suggests that the two genes may have overlapping functions in the regulation of gene expression during spermatogenesis in the adult mouse. However, Sox6 may have an additional role in the mouse embryo, where It is specifically expressed in the developing nervous system.
+;Present address: Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
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