Nucleic Acids Research, 1995, Vol. 23, No. 17 3481-3487
© 1995
MOLECULAR BIOLOGY |
Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer
Departments of Pediatrics, Yale University New Haven, CT 06520, USA 1Molecular Biophysics and Biochemisy Yale University New Haven, CT 06520, USA
*To whom correspondence should be addressed at present address: Department of Biology. Room 3100A Pacific Hall, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093–0357, USA
Received May 15, 1995. Revised July 18, 1995. Accepted July 18, 1995.
esophageal ganglion of the embryonic central nervous system. This Neural autoregulatory enhancer (NAE) maps in the large Dfd intron just upstream of the homeobox exon and requires Dfd protein function for its full activity. A 608 bp NAE subfragment retains regulatory function that is principally localized in the subesophageal ganglion. This small region of the Drosophila melanogaster genome contains numerous blocks of sequence conservation with a comparable region from the Dfd locus of D.hydei. A pair of conserved blocks of NAE sequence match a Dfd protein binding site in the epidermal autoregulatory element, while another conserved sequence motif is repeated multiple times within the 608 bp subelement.
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