Nucleic Acids Research, 1995, Vol. 23, No. 21 4262-4266
© 1995
Articles |
The gene for the human architectural transcription factor HMGI-C consists ofn five exons each coding for a distinct functional element
1Biophysics Laboratories, University of Portsmouth Portsmouth P01 2DT, UK 2Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University Hong Kong 3Department of Biochemistry,Hong Kong University of Science and Technology Hong Kong
*To whom correspondence should be addressed
Received August 25, 1995. Accepted September 25, 1995.
The gene on chromosome 12 coding for the human protein HMGI-C has been cloned and partially sequenced. It consists of five exons, the first and last of which include long untranslated regions. The 5' UTR Includes a (CA/T)n tract and a polymorphic (CT)n tract. Exons II, III and IV (87,51 and 33 bp) are dispersed over 
30 kb. Exons Mil separately encode the three basic DNA binding domains (‘A-T hooks’), exon IV encodes an 11 amino acid sequence characteristic of HMGI-C and absent from the human HMGI(Y) gene [Friedmann. M., Holth.L.T, Zoghbi,H.Y. and Reeves.R. (1993) Nucleic Acids Res., 21, 4259-1267], whilst exon V encodes the acidic C-terminal domain, which is subject to multiple phosphorylation. The HMGI-C gene is thus a striking example of the separation of functional protein elements into different coding exons.
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