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Nucleic Acids Research, 1995, Vol. 23, No. 21 4267-4274
© 1995

Articles

MEF2 proteins, including MEF2A, are expressed in both muscle and non-muscle cells

Evdokia Dodou, Duncan B. Sparrow1, Tim Mohun1 and Richard Treisman*

Transcription Laboratory, ICRF Laboratories, 44 Lincolns Inn Fields London WC2A 3PX, UK 1Developmental Biochemistry Laboratory, National Institute for Medical Research The Ridgeway, Mill Hill, London NW7 1AA, UK

*To whom correspondence should be addressed

Received August 24, 1995. Accepted October 6, 1995.

The MEF2 proteins are involved in regulation of many muscle specific genes. Although MEF2 RNAs encoding the MEF2A and MEF2D isoforms are ubiquitously expressed, the presence of MEF2 proteins In nonmuscle cell types has been controversial. Here we use a well-characterised antibody in conjunction with DNA binding studies to provide evidence that members of the MEF2 family are widely expressed in the nuclei of cultured cells and are competent to bind DNA. The data show that non-muscle MEF2 complexes contain MEF2A, and that another MEF2 protein, probably MEF2D, is also present. These results suggest that MEF2 proteins fulfil functions in addition to musclespecific gene expression.


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