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Nucleic Acids Research, 1995, Vol. 23, No. 22 4642-4648
© 1995

Articles

The effects of the ring fragmentation product of thymidine C5-hydrate on phosphodiestrases and klenow (exo-)fragment

Tracy J. Matray, karin J. Haxton and Marc M. Greenberg*

Department of Chemistry, Colorado State University Fort Collins, CO 80523, USA

*To whom correspondence should be addressed

Received August 9, 1995. Accepted October 12, 1995.

N-(2-Deoxy-ß-D-erythro-pentofuranosyl)-N-3-(2Rhydroxyisobutyric acid)urea ({alpha}-R-hydroxyisobutyric acid)urea ({alpha}R-hydroxy-ß-ureldoisobutyric acid, B) was site specifically incorporated into a series of oligonucleotides via the ammonolysis of biopolymers containing 5R-thymidlne C5-hydrate (3). {alpha}-R-hydroxy-ß-ureidoisobutyric acid (8) Inhibits snake venom phosphodiesterase, X{lambda}exonuclease and Klenow (exo~) fragment. Kinetic measurements for insertion of nucleotldes opposite 8 by Klenow (exo~) fragment Indicate that this lesion is Instructive.


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