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Nucleic Acids Research, 1995, Vol. 23, No. 3 467-474
© 1995

MOLECULAR BIOLOGY

Complex expression of murine heat shock transcription factors

Maria Teresa Fiorenza1, Thomas Farkas1, Marianne Dissing1, Dorthe Kolding2 and Vincenzo Zimarino1,3,*

1Department of Molecular Cell Biology, University of Copenhagen Denmark 2Statens Seruminstitut Copenhagen, Denmark 3Department of Biotechnology-HS Raffaele Via Olgettina 60, 20132 Milano, Italy

*To whom correspondence should be addressed at HS Raffaele, Department of Biotechnology (DIBIT), Room 2A2-39, Via Olgettina 60, 20132 Milano, Italy

Received September 23, 1994. Revised December 19, 1994. Accepted December 19, 1994.

A central step in the transcriptional activation of heat shock genes Is the binding of the heat shock factor (HSF) to upstream heat shock elements (HSEs). In vertebrates, HSF1 mediates the ubiquitous response to stress stimuli, while the role of a second HSE-bind-ing factor, HSF2, is still unclear. In this work we show that both factors are expressed In a wide range of murine tissues and each exists as two splicing isoforms. Although HSFs are virtually ubiquitous proteins, their abundance is predominant in testls and variable among other tissues, indicating specific regulations of their expression. A low level of DNA-bindlng activity of HSF1, detected in many tissues, Is probably physiological and is not explained by an anomalous regulation of one of the two isoforms. Our observations suggest that these regulatory proteins may all have roles in fully developed tissues. This possibility Is not mutually exclusive of a role of HSF2 during cellular differentiation and tissue development [L. Sistonen, K. D. Sarge and R. I. Morimoto (1994), Mol. Cell. Blol., 14, 2087-2099].


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