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Nucleic Acids Research, 1995, Vol. 23, No. 6 962-966
© 1995

MOLECULAR BIOLOGY

Late induction of human DNA ligase I after UV-C irradiation

Alessandra Montecucco, Elena Savini, Giuseppe Biamonti, Miria Stefanini, Federico Focher and Giovanni Ciarrocchi*

Istituto di Genetica Biochimica ed Evoluzionistica CNR, via Abbiategrasso 207, 27100 Pavia, Italy

*To whom correspondence should be addressed

Received December 5, 1994. Revised February 3, 1995. Accepted February 3, 1995.

We have studied the regulation of DNA ligase I gene expression In UV-C irradiated human primary fibro-blasts. An increase of -6-fold both in DNA ligase I messenger and activity levels was observed 24 h after UV treatment, when nucleotide excision repair (NER) Is no longer operating. DNA ligase I Induction is serum-independent and is controlled mainly by the steady-state level of its mRNA. The activation is a function of the UV dose and occurs at lower doses in cells showing UV hypersensitivity. No increase in replicative DNA polymerase {alpha} activity was found, Indicating that UV induction of DNA ligase I occurs through a pathway that differs from the one causing activation of the replication machinery. These data suggest that DNA ligase I induction could be linked to the repair of DNA damage not removed by NER.


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