Nucleic Acids Research, 1995, Vol. 23, No. 7 1127-1132
© 1995
MOLECULAR BIOLOGY |
A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm
Unité des Virus Oncogènes, UA1644 du CNRS, Département des Biotechnologies Institut Pasteur, 75724 Paris cedex 15, France 1Whitehead institute for Biomedical Research 9 Cambridge Center, Cambridge, MA 02142, USA
*To whom correspondence should be addressed
Received January 23, 1995. Revised February 17, 1995. Accepted February 17, 1995.
In yeast, the SNF/SWI complex is involved in transcriptional activation of several inducible promoters, possiblyby causing a local modification of the chromatin structure. Recently, two human homologues of the SNF2/SWI2 proteinhave been isolated, hbrm and BAG-1. In addition, a complex containing one of the SNF2/SWI2 homologues and having anIn vitro activity similar to the yeast complex has been partially purified from HeLa cells. Here we describe the characterization of a cDNA encoding a human nuclear protein containing a large domain of homology with SNF5, another member of the yeast SNF/SW1 complex. This protein can be co-immunoprecipitated with hbrm and the interaction between the two proteins is dependent on the region conserved between the human and the yeast SNF5. These findings suggest that the cDNA we have cloned encodes one of the members of the human SNF/SWI complex.
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