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Nucleic Acids Research, 1995, Vol. 23, No. 8 1279-1283
© 1995

SURVEY & SUMMARY

Macronuclear gene-sized molecules of hypotrichs

David C. Hoffman, Richard C. Anderson, Michelle L. DuBois and David M. Prescott*

University of Colorado, Department of Molecular, Cellular and Developmental Biology Boulder, CO 80309–0347, USA

* To whom correspondence should be addressed

Received December 12, 1994. Revised March 1, 1995. Accepted March 1, 1995.

The macronuclear genome of hypotrichous ciliates consists of DNA molecules of gene-sized length. A macronuclear DNA molecule contains a single coding region. We have analyzed the many hypotrich macro-nuclear DNA sequences sequenced by us andothers. No highly conserved promoter sequences nor replication initiation sequences have been identified in the 5' nor in the 3' non-translated regions, suggesting that promoter function in hypotrichs may differ from other eukaryotes. The macronuclear genes are intron-poor; ~19% of the genes sequenced to date have one to three introns. Not all macronuclear DNA molecules may be transcribed; some macronuclear molecules may not have any coding function. Codonias in hypotrichs is different in many respects from other ciliates and from other eukaryotes.


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