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Nucleic Acids Research, 1995, Vol. 23, No. 8 1396-1397
© 1995

MOLECULAR BIOLOGY

Xenopus egg lysates repair heat-generated DNA nicks with an average patch size of 36 nucleotides

Liane Höfferer, Kaspar H. Winterhalter1 and Felix R. Althaus*

Institute of Pharmacology and Toxicology, University of Zurich Winterthurerstrasse 260, 8057 Zürich, Switzerland 1Laboratory of Biochemistry I, ETH Zürich, Universitätsstrasse 16, 8092 Zürich, Switzerland

*To whom correspondence should be addressed

Received December 15, 1994. Revised March 10, 1995. Accepted March 10, 1995.

Base excision repair (BER) is an essential DNA repair pathway since it processes spontaneous (endogenous) DNA damage such as abasic sites, oxidized and alkylated bases, as well as mismatches arising from deamination of cytosine and 5-methylcytosine. Some of these lesions are repaired by the exchange of a single deoxynucleotide [Dianov, G. et al(1992) Mol Cell. Biol. 12, 1605–1612; Wiebauer, K. and Jiricny, J. (1990) Proc. Natl. Acad. Sci USA, 87, 5842–5845] or a few deoxynucleotides [Matsumoto, Y. et al. (1994) Mol Cell Biol., 14 6187–6197]. Here we report that DNA single strand breaks induced by hyperthermic conditions are repaired with an average patch size of ~36 nt in Xenopus laevis egg lysates.


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[Abstract] [Full Text]


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