Nucleic Acids Research, 1995, Vol. 23, No. 9 1536-1543
© 1995
MOLECULAR BIOLOGY |
Transcriptional activation by the orphan nuclear receptor ARP-1
Department of Cardiovascular Molecular Biology Lederle Laboratories, 401 North Middletown Road, Pearl River, NY 10965, USA
* To whom correspondence should be addressed
Received December 20, 1994. Revised March 13, 1995. Accepted March 13, 1995.
ARP-1 is a ubiquitous orphan nuclear receptor that binds to a site (site A) in the apolipoprotein Al (apoAl) liver-specific enhancer and represses its transcriptional activity In hepatoblastoma HepG2 cells. Electro-phoretic mobility shift analysis of HepG2 cell nuclear extracts showed that in addition to ARP-1, site A also binds the orphan nuclear receptors Ear-2 and HNF-4. In in vitro transcription assays, Hela cell nuclear extracts which contain ARP-1 had no effect on transcription from a basal promoter linked to multiple copies of site A. However, supplementation of these extracts with excess amounts of recomblnant ARP-1 resulted In significant stimulation. Supplementation of the extracts with purified polypeptides representing fusions between the ARP-1 N- or C-terminal domains and the yeast activator GAL4 DNA binding domain also stimulated transcription from a basal promoter linked to multiple GAL4 DNA binding sites. Co-immunopreci-prtatlon assays using ARP-1-selective antibodies revealed specific physical Interactions between ARP-1 and the basal transcription factor TFIIB. We conclude that ARP-1 possesses Intrinsic transcription activation potential which is modulated, at least In part, by the intracellular balance of other nuclear receptors that also bind to its cognate DNA binding site.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Takahashi, S. Martin-Brown, M. P. Washburn, L. Florens, J. W. Conaway, and R. C. Conaway Proteomics Reveals a Physical and Functional Link between Hepatocyte Nuclear Factor 4{alpha} and Transcription Factor IID J. Biol. Chem., November 20, 2009; 284(47): 32405 - 32412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Rufibach, S. A. Duncan, M. Battle, and S. S. Deeb Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter J. Lipid Res., July 1, 2006; 47(7): 1463 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. U. De Martino, N. Bhattachryya, S. Alesci, T. Ichijo, G. P. Chrousos, and T. Kino The Glucocorticoid Receptor and the Orphan Nuclear Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II Interact with and Mutually Affect Each Other's Transcriptional Activities: Implications for Intermediary Metabolism Mol. Endocrinol., April 1, 2004; 18(4): 820 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sato, T. Suzuki, K. Hidaka, H. Sato, K. Ito, S. Ito, and H. Sasano Immunolocalization of Nuclear Transcription Factors, DAX-1 and COUP-TF II, in the Normal Human Ovary: Correlation with Adrenal 4 Binding Protein/ Steroidogenic Factor-1 Immunolocalization during the Menstrual Cycle J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3415 - 3420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Malik, A. E. Wallberg, Y. K. Kang, and R. G. Roeder TRAP/SMCC/Mediator-Dependent Transcriptional Activation from DNA and Chromatin Templates by Orphan Nuclear Receptor Hepatocyte Nuclear Factor 4 Mol. Cell. Biol., August 1, 2002; 22(15): 5626 - 5637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Pineda Torra, Y. Jamshidi, D. M. Flavell, J.-C. Fruchart, and B. Staels Characterization of the Human PPAR{alpha} Promoter: Identification of a Functional Nuclear Receptor Response Element Mol. Endocrinol., May 1, 2002; 16(5): 1013 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Suzuki, K. Takahashi, A. D. Darnel, T. Moriya, O. Murakami, T. Narasaka, J. Takeyama, and H. Sasano Chicken Ovalbumin Upstream Promoter Transcription Factor II in the Human Adrenal Cortex and Its Disorders J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2752 - 2757. [Abstract] [Full Text]
|
|
|
|
|
|
D. Stroup and J. Y. L. Chiang HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7{alpha}-hydroxylase gene (CYP7A1) J. Lipid Res., January 1, 2000; 41(1): 1 - 11. [Abstract] [Full Text]
|
|
|
|
|
|
D.-Q. Lou, M. Tannour, L. Selig, D. Thomas, A. Kahn, and M. Vasseur-Cognet Chicken Ovalbumin Upstream Promoter-Transcription Factor II, a New Partner of the Glucose Response Element of the L-type Pyruvate Kinase Gene, Acts as an Inhibitor of the Glucose Response J. Biol. Chem., October 1, 1999; 274(40): 28385 - 28394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Avram, J. E. Ishmael, D. J. Nevrivy, V. J. Peterson, S.-H. Lee, P. Dowell, and M. Leid Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 J. Biol. Chem., May 14, 1999; 274(20): 14331 - 14336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pipaon, S. Y. Tsai, and M.-J. Tsai COUP-TF Upregulates NGFI-A Gene Expression through an Sp1 Binding Site Mol. Cell. Biol., April 1, 1999; 19(4): 2734 - 2745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Swenson, E. A. Mann, M. L. Jump, and R. A. Giannella Hepatocyte nuclear factor-4 regulates intestinal expression of the guanylin/heat-stable toxin receptor Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G728 - G736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Crestani, A. Sadeghpour, D. Stroup, G. Galli, and J. Y. L. Chiang Transcriptional activation of the cholesterol 7{alpha}-hydroxylase gene (CYP7A) by nuclear hormone receptors J. Lipid Res., November 1, 1998; 39(11): 2192 - 2200. [Full Text]
|
|
|
|
 |
|
 A. Farsetti, F. Moretti, M. Narducci, S. Misiti, S. Nanni, M. Andreoli, A. Sacchi, and A. Pontecorvi Orphan Receptor Hepatocyte Nuclear Factor-4 Antagonizes Estrogen Receptor {alpha}-Mediated Induction of Human Coagulation Factor XII Gene Endocrinology, November 1, 1998; 139(11): 4581 - 4589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kardassis, E. Sacharidou, and V. I. Zannis Transactivation of the Human Apolipoprotein CII Promoter by Orphan and Ligand-dependent Nuclear Receptors. THE REGULATORY ELEMENT CIIC IS A THYROID HORMONE RESPONSE ELEMENT J. Biol. Chem., July 10, 1998; 273(28): 17810 - 17816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Harnish, M. J. Evans, M. S. Scicchitano, R. A. Bhat, and S. K. Karathanasis Estrogen Regulation of the Apolipoprotein AI Gene Promoter through Transcription Cofactor Sharing J. Biol. Chem., April 10, 1998; 273(15): 9270 - 9278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Rohr, D. Aunis, and E. Schaeffer COUP-TF and Sp1 Interact and Cooperate in the Transcriptional Activation of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat in Human Microglial Cells J. Biol. Chem., December 5, 1997; 272(49): 31149 - 31155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lazennec, T. R. Ediger, L. N. Petz, A. M. Nardulli, and B. S. Katzenellenbogen Mechanistic Aspects of Estrogen Receptor Activation Probed with Constitutively Active Estrogen Receptors: Correlations with DNA and Coregulator Interactions and Receptor Conformational Changes Mol. Endocrinol., August 1, 1997; 11(9): 1375 - 1386. [Abstract] [Full Text]
|
|
|
|
|
|
D. Stroup, M. Crestani, and J. Y.L. Chiang Orphan Receptors Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) and Retinoid X Receptor (RXR) Activate and Bind the Rat Cholesterol 7alpha -Hydroxylase Gene (CYP7A) J. Biol. Chem., April 11, 1997; 272(15): 9833 - 9839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Garnier, A. Circolo, and H. R. Colten Constitutive Expression of Murine Complement Factor B Gene Is Regulated by the Interaction of Its Upstream Promoter with Hepatocyte Nuclear Factor 4 J. Biol. Chem., November 22, 1996; 271(47): 30205 - 30211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Marcus, C. J. Winrow, J. P. Capone, and R. A. Rachubinski A p56lck Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor J. Biol. Chem., November 1, 1996; 271(44): 27197 - 27200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Harnish, S. Malik, E. Kilbourne, R. Costa, and S. K. Karathanasis Control of Apolipoprotein AI Gene Expression through Synergistic Interactions between Hepatocyte Nuclear Factors 3and 4 J. Biol. Chem., June 7, 1996; 271(23): 13621 - 13628. [Abstract] [Full Text] [PDF]
|
|