Nucleic Acids Research, Vol 24, Issue 1 141-146, Copyright © 1996 by Oxford University Press
M Hollstein, B Shomer, M Greenblatt, T Soussi, E Hovig, R Montesano and CC Harris
In 1994 we described a list of approximately 2500 point mutations in the
p53 gene of human tumors and cell lines which we had compiled from the
published literature and made available electronically through the file
server at the EMBL Data Library. This database, updated twice a year, now
contains records on 4496 published mutations (July 1995 release) and can be
obtained from the EMBL Outstation-the European Bioinformatics Institute
(EBI) through the network or on CD-ROM. This report describes the criteria
for inclusion of data in this database, a description of the current format
and a brief discussion of the current relevance of p53 mutation analysis to
clinical and biological questions.
ARTICLES
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation
German Cancer Research Center, Heidelberg, Germany.
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 I Cruz, S S Napier, I van der Waal, P J F Snijders, J M M Walboomers, P J Lamey, C G Cowan, T A Gregg, P Maxwell, and C J L M Meijer Suprabasal p53 immunoexpression is strongly associated with high grade dysplasia and risk for malignant transformation in potentially malignant oral lesions from Northern Ireland J. Clin. Pathol., February 1, 2002; 55(2): 98 - 104. [Abstract] [Full Text] [PDF]
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P. A. Egner, J.-B. Wang, Y.-R. Zhu, B.-C. Zhang, Y. Wu, Q.-N. Zhang, G.-S. Qian, S.-Y. Kuang, S. J. Gange, L. P. Jacobson, et al. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer PNAS, November 20, 2001; (2001) 251536898. [Abstract] [Full Text] [PDF]
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P. Wolf, Y. C. Hu, K. Doffek, D. Sidransky, and S. A. Ahrendt O6-Methylguanine-DNA Methyltransferase Promoter Hypermethylation Shifts the p53 Mutational Spectrum in Non-Small Cell Lung Cancer Cancer Res., November 1, 2001; 61(22): 8113 - 8117. [Abstract] [Full Text] [PDF]
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X. Lu, G. Magrane, C. Yin, D. N. Louis, J. Gray, and T. Van Dyke Selective Inactivation of p53 Facilitates Mouse Epithelial Tumor Progression without Chromosomal Instability Mol. Cell. Biol., September 1, 2001; 21(17): 6017 - 6030. [Abstract] [Full Text] [PDF]
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 M. Sanchez-Beato, A. I. Saez, I. C. Navas, P. Algara, M. Sol Mateo, R. Villuendas, F. Camacho, A. Sanchez-Aguilera, E. Sanchez, and M. A. Piris Overall Survival in Aggressive B-Cell Lymphomas Is Dependent on the Accumulation of Alterations in p53, p16, and p27 Am. J. Pathol., July 1, 2001; 159(1): 205 - 213. [Abstract] [Full Text] [PDF]
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K. H. Vahakangas, W. P. Bennett, K. Castren, J. A. Welsh, M. A. Khan, B. Blomeke, M. C. R. Alavanja, and C. C. Harris p53 and K-ras Mutations in Lung Cancers from Former and Never-Smoking Women Cancer Res., June 1, 2001; 61(11): 4350 - 4356. [Abstract] [Full Text] [PDF]
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T. K. Hazra, J. G. Muller, R. C. Manuel, C. J. Burrows, R. S. Lloyd, and S. Mitra Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli Nucleic Acids Res., May 1, 2001; 29(9): 1967 - 1974. [Abstract] [Full Text] [PDF]
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M. S. Greenblatt, P. O. Chappuis, J. P. Bond, N. Hamel, and W. D. Foulkes TP53 Mutations in Breast Cancer Associated with BRCA1 or BRCA2 Germ-line Mutations: Distinctive Spectrum and Structural Distribution Cancer Res., May 1, 2001; 61(10): 4092 - 4097. [Abstract] [Full Text]
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 J. F Costello and C. Plass Methylation matters J. Med. Genet., May 1, 2001; 38(5): 285 - 303. [Abstract] [Full Text]
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L. A. Loeb A Mutator Phenotype in Cancer Cancer Res., April 1, 2001; 61(8): 3230 - 3239. [Abstract] [Full Text]
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 H.-L. Song, G. J.S. Jenkins, J. Ashby, H. Tinwell, and J. M. Parry The application of the restriction site mutation assay to compare 1-ethyl-1-nitrosourea-induced mutations between the endogenous p53 gene and the transgenic LacZ gene in MutaMouse testes Mutagenesis, January 1, 2001; 16(1): 59 - 64. [Abstract] [Full Text] [PDF]
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T. K. Hoffmann, K. Nakano, E. M. Elder, G. Dworacki, S. D. Finkelstein, E. Appella, T. L. Whiteside, and A. B. DeLeo Generation of T Cells Specific for the Wild-Type Sequence p53264-272 Peptide in Cancer Patients: Implications for Immunoselection of Epitope Loss Variants J. Immunol., November 15, 2000; 165(10): 5938 - 5944. [Abstract] [Full Text] [PDF]
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M. Audebert, S. Chevillard, C. Levalois, G. Gyapay, A. Vieillefond, J. Klijanienko, P. Vielh, A. K. El Naggar, S. Oudard, S. Boiteux, et al. Alterations of the DNA Repair Gene OGG1 in Human Clear Cell Carcinomas of the Kidney Cancer Res., September 1, 2000; 60(17): 4740 - 4744. [Abstract] [Full Text]
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J. Noolandi, T. S. Davison, A. R. Völkel, X.-F. Nie, C. Kay, and C. H. Arrowsmith A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53 PNAS, August 10, 2000; (2000) 160075697. [Abstract] [Full Text]
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 B. C. McKay, F. Chen, C. R. Perumalswami, F. Zhang, and M. Ljungman The Tumor Suppressor p53 Can Both Stimulate and Inhibit Ultraviolet Light-induced Apoptosis Mol. Biol. Cell, August 1, 2000; 11(8): 2543 - 2551. [Abstract] [Full Text]
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K. Husgafvel-Pursiainen, P. Boffetta, A. Kannio, F. Nyberg, G. Pershagen, A. Mukeria, V. Constantinescu, C. Fortes, and S. Benhamou p53 Mutations and Exposure to Environmental Tobacco Smoke in a Multicenter Study on Lung Cancer Cancer Res., June 1, 2000; 60(11): 2906 - 2911. [Abstract] [Full Text] [PDF]
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Y. C. Cai, G.-y. Yang, Y. Nie, L.-D. Wang, X. Zhao, Y.-l. Song, D. N. Seril, J. Liao, E. P. Xing, and C. S. Yang Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53 Carcinogenesis, April 1, 2000; 21(4): 683 - 689. [Abstract] [Full Text] [PDF]
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M. Laverdiere, J. Beaudoin, and A. Lavigueur Species-specific regulation of alternative splicing in the C-terminal region of the p53 tumor suppressor gene Nucleic Acids Res., March 15, 2000; 28(6): 1489 - 1497. [Abstract] [Full Text] [PDF]
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M. Wade and M. J. Allday Epstein-Barr Virus Suppresses a G2/M Checkpoint Activated by Genotoxins Mol. Cell. Biol., February 15, 2000; 20(4): 1344 - 1360. [Abstract] [Full Text]
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 M Levrero, V De Laurenzi, A Costanzo, J Gong, J. Wang, and G Melino The p53/p63/p73 family of transcription factors: overlapping and distinct functions J. Cell Sci., January 5, 2000; 113(10): 1661 - 1670. [Abstract] [PDF]
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 S.D. BRUNER, D.P.G. NORMAN, J.C. FROMME, and G.L. VERDINE Structural and Mechanistic Studies on Repair of 8-Oxoguanine in Mammalian Cells Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 103 - 112. [Abstract] [PDF]
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R. Alarcon, C. Koumenis, R. K. Geyer, C. G. Maki, and A. J. Giaccia Hypoxia Induces p53 Accumulation through MDM2 Down-Regulation and Inhibition of E6-mediated Degradation Cancer Res., December 1, 1999; 59(24): 6046 - 6051. [Abstract] [Full Text] [PDF]
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X. Tan, A. P. Grollman, and S. Shibutani Comparison of the mutagenic properties of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA lesions in mammalian cells Carcinogenesis, December 1, 1999; 20(12): 2287 - 2292. [Abstract] [Full Text] [PDF]
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 C. Mejia, A. Pellin, S. Navarro, V. Castel, and A. Llombart-Bosch A New Mutation of the p53 Gene in Human Neuroblastoma, Not Correlated with N-myc Amplification International Journal of Surgical Pathology, July 1, 1999; 7(3): 149 - 154. [Abstract] [PDF]
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M.-s. Tang, J. B. Zheng, M. F. Denissenko, G. P. Pfeifer, and Y. Zheng Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxide–DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene Carcinogenesis, June 1, 1999; 20(6): 1085 - 1089. [Abstract] [Full Text] [PDF]
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C. Zietz, M. Rossle, C. Haas, A. Sendelhofert, A. Hirschmann, M. Sturzl, and U. Lohrs MDM-2 Oncoprotein Overexpression, p53 Gene Mutation, and VEGF Up-Regulation in Angiosarcomas Am. J. Pathol., November 1, 1998; 153(5): 1425 - 1433. [Abstract] [Full Text] [PDF]
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S. N. Rodin and A. S. Rodin Strand asymmetry of CpG transitions as indicator of G1 phase-dependent origin of multiple tumorigenic p53 mutations in stem cells PNAS, September 29, 1998; 95(20): 11927 - 11932. [Abstract] [Full Text] [PDF]
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F. W. Quelle, J. Wang, J. Feng, D. Wang, J. L. Cleveland, J. N. Ihle, and G. P. Zambetti Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways Genes & Dev., April 15, 1998; 12(8): 1099 - 1107. [Abstract] [Full Text]
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 B. S. Strauss Hypermutability in Carcinogenesis Genetics, April 1, 1998; 148(4): 1619 - 1626. [Abstract] [Full Text] [PDF]
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S. Gnjatic, Z. Cai, M. Viguier, S. Chouaib, J.-G. Guillet, and J. Choppin Accumulation of the p53 Protein Allows Recognition by Human CTL of a Wild-Type p53 Epitope Presented by Breast Carcinomas and Melanomas J. Immunol., January 1, 1998; 160(1): 328 - 333. [Abstract] [Full Text] [PDF]
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 J. A. Welsh, K. Castren, and K. H. Vahakangas Single-strand conformation polymorphism analysis to detect p53 mutations: characterization and development of controls Clin. Chem., December 1, 1997; 43(12): 2251 - 2255. [Abstract] [Full Text] [PDF]
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D. J. Moshinsky and G. N. Wogan UV-induced mutagenesis of human p53 in a vector replicated in Saccharomyces cerevisiae PNAS, March 18, 1997; 94(6): 2266 - 2271. [Abstract] [Full Text] [PDF]
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M. Lieb and S. Rehmat 5-Methylcytosine is not a mutation hot spot in nondividing Escherichia coli PNAS, February 4, 1997; 94(3): 940 - 945. [Abstract] [Full Text] [PDF]
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 M. F. Denissenko, A. Pao, M.-s. Tang, and G. P. Pfeifer Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 Science, October 18, 1996; 274(5286): 430 - 432. [Abstract] [Full Text]
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M. T. Boyd, N. Vlatkovic, and D. S. Haines A Novel Cellular Protein (MTBP) Binds to MDM2 and Induces a G1 Arrest That Is Suppressed by MDM2 J. Biol. Chem., October 6, 2000; 275(41): 31883 - 31890. [Abstract] [Full Text] [PDF]
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V. Hegde, M. R. Kelley, Y. Xu, I. S. Mian, and W. A. Deutsch Conversion of the Bifunctional 8-Oxoguanine/beta -delta Apurinic/Apyrimidinic DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional beta -Elimination Catalyst through a Single Amino Acid Change J. Biol. Chem., July 13, 2001; 276(29): 27591 - 27596. [Abstract] [Full Text] [PDF]
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J. Noolandi, T. S. Davison, A. R. Volkel, X.-F. Nie, C. Kay, and C. H. Arrowsmith A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53 PNAS, August 29, 2000; 97(18): 9955 - 9960. [Abstract] [Full Text] [PDF]
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P. A. Egner, J.-B. Wang, Y.-R. Zhu, B.-C. Zhang, Y. Wu, Q.-N. Zhang, G.-S. Qian, S.-Y. Kuang, S. J. Gange, L. P. Jacobson, et al. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer PNAS, December 4, 2001; 98(25): 14601 - 14606. [Abstract] [Full Text] [PDF]
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