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Nucleic Acids Research, Vol 24, Issue 10 1928-1935, Copyright © 1996 by Oxford University Press

ARTICLES

Transcriptional regulation of the MHC class I HLA-A11 promoter by the zinc finger protein ZFX

M L'Haridon, P Paul, JG Xerri, H Dastot, C Dolliger, M Schmid, N de Angelis, L Grollet, F Sigaux, L Degos and C Gazin
INSERM U93, Centre Hayem, Paris, France.

Regulation of the human MHC class I HLA-A11 promoter is governed by a complex array of regulatory elements. One of these elements, shown here to be critical for the transcriptional activity of the promoter, was used to screen a lambda gt11 library and allowed the identification of a cDNA which coded for the zinc finger protein ZFX. ZFX was shown to bind the sequences AGGGCCCCA and AGGCCCCGA, located respectively at positions -271 to -263 and -242 to -234 of the HLA-A11 promoter, with similar affinities through its three C-terminal zinc fingers. ZFX575, a short isoform of ZFX, activates transcription from the HLA-All promoter in a Leydig cell line.
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