Nucleic Acids Research, Vol 24, Issue 12 2260-2267, Copyright © 1996 by Oxford University Press
A Lebrun and R Lavery
Molecular modelling with Jumna is used to study extreme stretching of the
DNA double helix. The results, which correlate well with recent
nanomanipulation experiments, show how the double helix can be extended to
twice its normal length before its base pairs break. Depending on the way
the duplex is stretched two types of conformation can occur, either an
unwound flat ribbon or a narrow fibre with negatively inclined base pairs.
The energetics of both types of deformation are similar and existing
structures show that at least the flat ribbon form can exist locally under
biological conditions.
ARTICLES
Modelling extreme stretching of DNA
Laboratoire de Biochimie Theorique, Institut de Biologie Physico- Chimique, Paris, France.
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