Nucleic Acids Research, Vol 24, Issue 15 2877-2884, Copyright © 1996 by Oxford University Press
DR Koehler and PC Hanawalt
We examined the relationship between the nuclear matrix and DNA in the
dihydrofolate reductase domain following irradiation of Chinese hamster
cells with UV light. The fraction of matrix-bound DNA increased in
transcribed and non-transcribed regions during a 3 h period after
irradiation. However, no increase was observed with excision repair-
deficient cells mutant for the ERCC1 gene. The major UV-induced lesion, the
cyclobutane pyrimidine dimer, increased in frequency in the matrix- bound
DNA 1 h after irradiation, in both transcribed and non- transcribed
regions, but decreased subsequently. This phenomenon was also lacking in
excision repair-deficient cells. These data demonstrate that recruitment of
lesion-containing DNA to the nuclear matrix occurs following UV irradiation
and suggest that this recruitment is dependent upon nucleotide excision
repair. This is consistent with the concept of a 'repair factory' residing
on the nuclear matrix at which excision repair occurs.
ARTICLES
Recruitment of damaged DNA to the nuclear matrix in hamster cells following ultraviolet irradiation
Department of Biological Sciences, Stanford University, CA 94305-5020, USA.
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