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Nucleic Acids Research, Vol 24, Issue 17 3357-3363, Copyright © 1996 by Oxford University Press

ARTICLES

Synthesis and properties of DNA-PNA chimeric oligomers

PJ Finn, NJ Gibson, R Fallon, A Hamilton and T Brown
Department of Chemistry, University of Southampton, Highfield, UK.

Adenine, thymine and cytosine PNA monomers have been prepared using 3- amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases of A and C PNA monomers and the backbone primary amine was protected with the monomethoxytrityl group. The thymine and cytosine PNA monomers were used in conjunction with standard DNA synthesis monomers to produce chimeric PNA DNA (PDC) oligomers. Ultraviolet melting studies confirmed that these oligomers form stable hybrids with complementary DNA strands and that mismatches in the DNA but more so in the PNA sections lead to duplex destabilisation.
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