Nucleic Acids Research, Vol 24, Issue 2 303-310, Copyright © 1996 by Oxford University Press
K Kawakami, H Ohto, K Ikeda and RG Roeder
The cDNA clones encoding ARE(Na,K-ATPase alpha1 subunit gene regulatory
element) binding protein AREC3 were isolated from myoblast C2C12 cells and
mouse skeletal muscle cDNA library. At least four alternatively spliced
forms of AREC3 cDNA were identified. Sequence analysis indicates that AREC3
has an extensive homology with the Drosophila sine oculis gene product
required for development of the entire visual system [Cheyette et al.(1994)
Neuron 12, 977-996]. The homologous region including a homeodomain is
required for specific DNA binding to ARE. A transactivation domain was
identified in the C-terminal part of the AREC3 by reporter gene assays
using GAL4-AREC3 fusion protein constructs. Immunohistochemistry revealed
that AREC3 localized to the nucleus and cytoplasm of myoblast C2C12 cells,
and the production of AREC3 is augmented during muscle differentiation.
Western blot analysis indicated that the 115 kDa form of AREC3 protein is
increased in the cytoplasmic extract, and the 67kDa form is increased both
in nuclear and cytoplasmic extracts of C2C12 cells during muscle
differentiation.
ARTICLES
Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development
Department of Biology, Jichi Medical School, Tochigi, Japan.
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