Nucleic Acids Research, Vol 24, Issue 2 303-310, Copyright © 1996 by Oxford University Press
K Kawakami, H Ohto, K Ikeda and RG Roeder
The cDNA clones encoding ARE(Na,K-ATPase alpha1 subunit gene regulatory
element) binding protein AREC3 were isolated from myoblast C2C12 cells and
mouse skeletal muscle cDNA library. At least four alternatively spliced
forms of AREC3 cDNA were identified. Sequence analysis indicates that AREC3
has an extensive homology with the Drosophila sine oculis gene product
required for development of the entire visual system [Cheyette et al.(1994)
Neuron 12, 977-996]. The homologous region including a homeodomain is
required for specific DNA binding to ARE. A transactivation domain was
identified in the C-terminal part of the AREC3 by reporter gene assays
using GAL4-AREC3 fusion protein constructs. Immunohistochemistry revealed
that AREC3 localized to the nucleus and cytoplasm of myoblast C2C12 cells,
and the production of AREC3 is augmented during muscle differentiation.
Western blot analysis indicated that the 115 kDa form of AREC3 protein is
increased in the cytoplasmic extract, and the 67kDa form is increased both
in nuclear and cytoplasmic extracts of C2C12 cells during muscle
differentiation.
ARTICLES
Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development
Department of Biology, Jichi Medical School, Tochigi, Japan.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. N. Patrick, B. J. Schiemann, K. Yang, R. Zhao, and H. L. Ford Biochemical and Functional Characterization of Six SIX1 Branchio-oto-renal Syndrome Mutations J. Biol. Chem., July 31, 2009; 284(31): 20781 - 20790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pauli, M. Seimiya, J. Blanco, and W. J. Gehring Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog Development, June 15, 2005; 132(12): 2771 - 2782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Himeda, J. A. Ranish, J. C. Angello, P. Maire, R. Aebersold, and S. D. Hauschka Quantitative Proteomic Identification of Six4 as the Trex-Binding Factor in the Muscle Creatine Kinase Enhancer Mol. Cell. Biol., March 1, 2004; 24(5): 2132 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ozaki, K. Nakamura, J.-i. Funahashi, K. Ikeda, G. Yamada, H. Tokano, H.-o. Okamura, K. Kitamura, S. Muto, H. Kotaki, et al. Six1 controls patterning of the mouse otic vesicle Development, February 1, 2004; 131(3): 551 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Silver, E. L. Davies, L. Doyon, and I. Rebay Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network Mol. Cell. Biol., September 1, 2003; 23(17): 5989 - 5999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Laclef, G. Hamard, J. Demignon, E. Souil, C. Houbron, and P. Maire Altered myogenesis in Six1-deficient mice Development, May 15, 2003; 130(10): 2239 - 2252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Zhu, M. A. Dyer, M. Uchikawa, H. Kondoh, O. V. Lagutin, and G. Oliver Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors Development, March 8, 2003; 129(12): 2835 - 2849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lopez-Rios, K. Tessmar, F. Loosli, J. Wittbrodt, and P. Bovolenta Six3 and Six6 activity is modulated by members of the groucho family Development, January 1, 2003; 130(1): 185 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ikeda, Y. Watanabe, H. Ohto, and K. Kawakami Molecular Interaction and Synergistic Activation of a Promoter by Six, Eya, and Dach Proteins Mediated through CREB Binding Protein Mol. Cell. Biol., October 1, 2002; 22(19): 6759 - 6766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Rivolta, A. Halsall, C. M. Johnson, M. A. Tones, and M. C. Holley Transcript Profiling of Functionally Related Groups of Genes During Conditional Differentiation of a Mammalian Cochlear Hair Cell Line Genome Res., July 1, 2002; 12(7): 1091 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sato, M. Nakamura, D. H. Cho, S. J. Tapscott, H. Ozaki, and K. Kawakami Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1 Hum. Mol. Genet., May 1, 2002; 11(9): 1045 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ozaki, Y. Watanabe, K. Takahashi, K. Kitamura, A. Tanaka, K. Urase, T. Momoi, K. Sudo, J. Sakagami, M. Asano, et al. Six4, a Putative myogenin Gene Regulator, Is Not Essential for Mouse Embryonal Development Mol. Cell. Biol., May 15, 2001; 21(10): 3343 - 3350. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. E. Harris, C. L. Winchester, and K. J. Johnson Functional analysis of the homeodomain protein SIX5 Nucleic Acids Res., May 1, 2000; 28(9): 1871 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pineda, J. Gonzalez, P. Callaerts, K. Ikeo, W. J. Gehring, and E. Salo Special Feature: Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians PNAS, April 25, 2000; 97(9): 4525 - 4529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Seimiya and W. Gehring The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism Development, January 5, 2000; 127(9): 1879 - 1886. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Relaix and M. Buckingham From insect eye to vertebrate muscle: redeployment of a regulatory network Genes & Dev., December 15, 1999; 13(24): 3171 - 3178. [Full Text]
|
|
|
|
|
|
H. Ohto, S. Kamada, K. Tago, S.-I. Tominaga, H. Ozaki, S. Sato, and K. Kawakami Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya Mol. Cell. Biol., October 1, 1999; 19(10): 6815 - 6824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Loosli, S. Winkler, and J. Wittbrodt Six3 overexpression initiates the formation of ectopic retina Genes & Dev., March 15, 1999; 13(6): 649 - 654. [Abstract] [Full Text]
|
|
|
|
|
|
B. Hauck, W. J. Gehring, and U. Walldorf Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila PNAS, January 19, 1999; 96(2): 564 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Spitz, J. Demignon, A. Porteu, A. Kahn, J.-P. Concordet, D. Daegelen, and P. Maire Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site PNAS, November 24, 1998; 95(24): 14220 - 14225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Toy, J.-M. Yang, G. S. Leppert, and O. H. Sundin The Optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes PNAS, September 1, 1998; 95(18): 10643 - 10648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Kobayashi, R Toyama, H Takeda, I. Dawid, and K Kawakami Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish Development, January 8, 1998; 125(15): 2973 - 2982. [Abstract] [PDF]
|
|