Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (124K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Iouzalen, N
Right arrow Articles by Mechali, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iouzalen, N
Right arrow Articles by Mechali, M
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, Vol 24, Issue 20 3947-3952, Copyright © 1996 by Oxford University Press

ARTICLES

H2A.ZI, a new variant histone expressed during Xenopus early development exhibits several distinct features from the core histone H2A

N Iouzalen, J Moreau and M Mechali
Institut Jacques Monod, Molecular Embryology, Paris, France.

We have isolated from a subtractive cDNA library of Xenopus laevis a novel transcript, H2A.ZI, which belongs to the H2A.Z variant gene family. Characterization of its expression during oogenesis and development shows significant differences from the expression of the core histone H2A. First, H2A.ZI mRNA is mainly detected only during oogenesis and after the midblastula transition, whereas H2A is constitutively expressed, at much higher levels, throughout embryonic growth. Second, in contrast with H2A, the variant H2A.ZI is polyadenylated during development. Third, expression of H2A.ZI is uncoupled from the S phase after gastrula, whereas synthesis of the core histone H2A mRNA is tightly controlled to DNA replication. Interestingly, H2A.ZI is less charged in the N-terminal tail which is crucial for chromatin-mediated repression. The characteristics of H2A.ZI suggest that its incorporation into nucleosomes would lead to a chromatin structure more competent for gene expression during development.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Plant CellHome page
H. Yi, N. Sardesai, T. Fujinuma, C.-W. Chan, Veena, and S. B. Gelvin
Constitutive Expression Exposes Functional Redundancy between the Arabidopsis Histone H2A Gene HTA1 and Other H2A Gene Family Members
PLANT CELL, July 1, 2006; 18(7): 1575 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. E. Lowell, F. Kaiser, C. J. Janzen, and G. A. M. Cross
Histone H2AZ dimerizes with a novel variant H2B and is enriched at repetitive DNA in Trypanosoma brucei
J. Cell Sci., December 15, 2005; 118(24): 5721 - 5730.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Ridgway, K. D. Brown, D. Rangasamy, U. Svensson, and D. J. Tremethick
Unique Residues on the H2A.Z Containing Nucleosome Surface Are Important for Xenopus laevis Development
J. Biol. Chem., October 15, 2004; 279(42): 43815 - 43820.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.