Nucleic Acids Research, Vol 24, Issue 22 4387-4394, Copyright © 1996 by Oxford University Press
KW Caldecott, S Aoufouchi, P Johnson and S Shall
The DNA repair proteins XRCC1 and DNA ligase III are physically associated
in human cells and directly interact in vitro and in vivo. Here, we
demonstrate that XRCC1 is additionally associated with DNA polymerase-beta
in human cells and that these polypeptides also directly interact. We also
present data suggesting that poly (ADP- ribose) polymerase can interact
with XRCC1. Finally, we demonstrate that DNA ligase III shares with poly
(ADP-ribose) polymerase the novel function of a molecular DNA nick-sensor,
and that the DNA ligase can inhibit activity of the latter polypeptide in
vitro. Taken together, these data suggest that the activity of the four
polypeptides described above may be co-ordinated in human cells within a
single multiprotein complex.
ARTICLES
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick- sensor' in vitro
Zeneca Laboratory for Cell and Molecular Biology, School of Biological Sciences, University of Manchester, UK. keith.caldecott@man.ac.uk
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E. J. Duell, E. A. Holly, P. M. Bracci, J. K. Wiencke, and K. T. Kelsey A Population-based Study of the Arg399Gln Polymorphism in X-Ray Repair Cross- Complementing Group 1 (XRCC1) and Risk of Pancreatic Adenocarcinoma Cancer Res., August 15, 2002; 62(16): 4630 - 4636. [Abstract] [Full Text] [PDF]
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A. Saxena, R. Saffery, L. H. Wong, P. Kalitsis, and K. H. A. Choo Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated J. Biol. Chem., July 19, 2002; 277(30): 26921 - 26926. [Abstract] [Full Text] [PDF]
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S. Petrucco, G. Volpi, A. Bolchi, C. Rivetti, and S. Ottonello A Nick-sensing DNA 3'-Repair Enzyme from Arabidopsis J. Biol. Chem., June 21, 2002; 277(26): 23675 - 23683. [Abstract] [Full Text] [PDF]
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M. A. Pope, S. L. Porello, and S. S. David Escherichia coli Apurinic-Apyrimidinic Endonucleases Enhance the Turnover of the Adenine Glycosylase MutY with G:A Substrates J. Biol. Chem., June 14, 2002; 277(25): 22605 - 22615. [Abstract] [Full Text] [PDF]
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V. Schreiber, J.-C. Ame, P. Dolle, I. Schultz, B. Rinaldi, V. Fraulob, J. Menissier-de Murcia, and G. de Murcia Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1 J. Biol. Chem., June 14, 2002; 277(25): 23028 - 23036. [Abstract] [Full Text] [PDF]
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B. Pascucci, G. Maga, U. Hubscher, M. Bjoras, E. Seeberg, I. D. Hickson, G. Villani, C. Giordano, L. Cellai, and E. Dogliotti Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins Nucleic Acids Res., May 15, 2002; 30(10): 2124 - 2130. [Abstract] [Full Text] [PDF]
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R. M. Taylor, A. Thistlethwaite, and K. W. Caldecott Central Role for the XRCC1 BRCT I Domain in Mammalian DNA Single-Strand Break Repair Mol. Cell. Biol., April 15, 2002; 22(8): 2556 - 2563. [Abstract] [Full Text] [PDF]
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S.-Y. Park, W. Lam, and Y.-c. Cheng X-ray Repair Cross-Complementing Gene I Protein Plays an Important Role in Camptothecin Resistance Cancer Res., January 1, 2002; 62(2): 459 - 465. [Abstract] [Full Text] [PDF]
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G. Matullo, D. Palli, M. Peluso, S. Guarrera, S. Carturan, E. Celentano, V. Krogh, A. Munnia, R. Tumino, S. Polidoro, et al. XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects Carcinogenesis, September 1, 2001; 22(9): 1437 - 1445. [Abstract] [Full Text] [PDF]
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S. L. Donahue, B. E. Corner, L. Bordone, and C. Campbell Mitochondrial DNA ligase function in Saccharomyces cerevisiae Nucleic Acids Res., April 1, 2001; 29(7): 1582 - 1589. [Abstract] [Full Text] [PDF]
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G. W. Intano, C. A. McMahan, R. B. Walter, J. R. McCarrey, and C. A. Walter Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity Nucleic Acids Res., March 15, 2001; 29(6): 1366 - 1372. [Abstract] [Full Text] [PDF]
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E. J. Duell, R. C. Millikan, G. S. Pittman, S. Winkel, R. M. Lunn, C.-K. J. Tse, A. Eaton, H. W. Mohrenweiser, B. Newman, and D. A. Bell Polymorphisms in the DNA Repair Gene XRCC1 and Breast Cancer Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 217 - 222. [Abstract] [Full Text]
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M. C. Stern, D. M. Umbach, C. H. van Gils, R. M. Lunn, and J. A. Taylor DNA Repair Gene XRCC1 Polymorphisms, Smoking, and Bladder Cancer Risk Cancer Epidemiol. Biomarkers Prev., February 1, 2001; 10(2): 125 - 131. [Abstract] [Full Text]
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U. Lakshmipathy and C. Campbell Mitochondrial DNA ligase III function is independent of Xrcc1 Nucleic Acids Res., October 15, 2000; 28(20): 3880 - 3886. [Abstract] [Full Text] [PDF]
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 F. Tramontano, M. Malanga, B. Farina, R. Jones, and P. Quesada Heat stress reduces poly(ADPR)polymerase expression in rat testis Mol. Hum. Reprod., July 1, 2000; 6(7): 575 - 581. [Abstract] [Full Text] [PDF]
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A. Marintchev, A. Robertson, E. K. Dimitriadis, R. Prasad, S. H. Wilson, and G. P. Mullen Domain specific interaction in the XRCC1-DNA polymerase {beta} complex Nucleic Acids Res., May 15, 2000; 28(10): 2049 - 2059. [Abstract] [Full Text] [PDF]
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R. M. Taylor, D. J. Moore, J. Whitehouse, P. Johnson, and K. W. Caldecott A Cell Cycle-Specific Requirement for the XRCC1 BRCT II Domain during Mammalian DNA Strand Break Repair Mol. Cell. Biol., January 15, 2000; 20(2): 735 - 740. [Abstract] [Full Text]
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 M. Fujimura, Y. Morita-Fujimura, T. Sugawara, P. H. Chan, and C. Y. Hsu Early Decrease of XRCC1, a DNA Base Excision Repair Protein, May Contribute to DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice • Editorial Comment Stroke, November 1, 1999; 30(11): 2456 - 2463. [Abstract] [Full Text] [PDF]
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L. Liu, P. Taverna, C. M. Whitacre, S. Chatterjee, and S. L. Gerson Pharmacologic Disruption of Base Excision Repair Sensitizes Mismatch Repair-deficient and -proficient Colon Cancer Cells to Methylating Agents Clin. Cancer Res., October 1, 1999; 5(10): 2908 - 2917. [Abstract] [Full Text] [PDF]
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Z. B. Mackey, C. Niedergang, J. M.-d. Murcia, J. Leppard, K. Au, J. Chen, G. de Murcia, and A. E. Tomkinson DNA Ligase III Is Recruited to DNA Strand Breaks by a Zinc Finger Motif Homologous to That of Poly(ADP-ribose) Polymerase. IDENTIFICATION OF TWO FUNCTIONALLY DISTINCT DNA BINDING REGIONS WITHIN DNA LIGASE III J. Biol. Chem., July 30, 1999; 274(31): 21679 - 21687. [Abstract] [Full Text] [PDF]
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W. P. Osheroff, H. K. Jung, W. A. Beard, S. H. Wilson, and T. A. Kunkel The Fidelity of DNA Polymerase beta during Distributive and Processive DNA Synthesis J. Biol. Chem., February 5, 1999; 274(6): 3642 - 3650. [Abstract] [Full Text] [PDF]
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F. J. Oliver, G. de la Rubia, V. Rolli, M. C. Ruiz-Ruiz, G. de Murcia, and J. M.-d. Murcia Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis. LESSON FROM AN UNCLEAVABLE MUTANT J. Biol. Chem., December 11, 1998; 273(50): 33533 - 33539. [Abstract] [Full Text] [PDF]
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 P. Baumann and S. C. West DNA end-joining catalyzed by human cell-free extracts PNAS, November 24, 1998; 95(24): 14066 - 14070. [Abstract] [Full Text] [PDF]
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D. K. Srivastava, B. J. Vande Berg, R. Prasad, J. T. Molina, W. A. Beard, A. E. Tomkinson, and S. H. Wilson Mammalian Abasic Site Base Excision Repair. IDENTIFICATION OF THE REACTION SEQUENCE AND RATE-DETERMINING STEPS J. Biol. Chem., August 14, 1998; 273(33): 21203 - 21209. [Abstract] [Full Text] [PDF]
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