Nucleic Acids Research, Vol 24, Issue 24 4874-4881, Copyright © 1996 by Oxford University Press
P Spaniol, C Bornmann, G Hauptmann and T Gerster
POU genes encode a family of transcription factors involved in a wide
variety of cell fate decisions and in the regulation of differentiation
pathways. We have searched for POU genes in the zebrafish, a popular model
organism for the study of early development of vertebrates. Besides five
putative pseudogenes we have identified five POU genes that are expressed
during embryogenesis. Probes obtained by PCR were used to isolate
full-length cDNAs. Four of the isolated genes encode proteins with class
III POU domains. Analysis of genomic clones suggests that the fish genes in
general do not contain introns, similar to class III genes of mammals.
However, the C-termini of two of the encoded proteins vary due to
facultative splicing of a short intervening sequence. These two genes show
very strong similarities in their sequence. They have probably arisen by
gene duplication, possibly as part of a larger scale duplication of part of
the zebrafish genome. Analysis of the expression of the class III genes
shows that they are predominantly expressed in the central nervous system
and that they may play important roles in patterning the embryonic brain.
ARTICLES
Class III POU genes of zebrafish are predominantly expressed in the central nervous system
Biozentrum der Universitat Basel, Abteilung Zellbiologie, Switzerland.
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