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Nucleic Acids Research, Vol 24, Issue 24 4940-4945, Copyright © 1996 by Oxford University Press

ARTICLES

Isoguanine quartets formed by d(T4isoG4T4): tetraplex identification and stability

F Seela, C Wei and A Melenewski
Laboratorium fur Organische und Bioorganische Chemie, Universitat Osnabruck, Germany. fraseela@rz.uni-osnabrueck.de

The self-aggregation of the oligonucleotide d(T4isoG4T4) (1) is investigated. Based on ion exchange HPLC experiments and CD spectroscopy, a tetrameric structure is identified. This structure was formed in the presence of sodium ions and shows almost the same chromatographic mobility on ion exchange HPLC as d(T4G4T4) (2). The ratio of aggregate versus monomer is temperature dependent and the tetraplex of [d(T4isoG4T4)]4 is more stable than that of [d(T4G4T4)]4. A mixture of d(T4isoG4T4) and d(T4G4T4) forms mixed tetraplexes containing strands of d(T4isoG4T4) and d(T4G4T4).
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