Nucleic Acids Research, Vol 24, Issue 5 803-807, Copyright © 1996 by Oxford University Press
P Emery, B Durand, B Mach and W Reith
Until recently, the RFX family of DNA binding proteins consisted
exclusively of four mammalian members (RFX1-RFX4) characterized by a novel
highly conserved DNA binding domain. Strong conservation of this DNA
binding domain precluded a precise definition of the motif required for DNA
binding. In addition, the biological systems in which these RFX proteins
are implicated remained obscure. The recent identification of four new RFX
genes has now shed light on the evolutionary conservation of the RFX
family, contributed greatly to a detailed characterization of the RFX DNA
binding motif, and provided clear evidence for the function of some of the
RFX proteins. RFX proteins have been conserved throughout evolution in a
wide variety of species, including Saccharomyces cerevisiae,
Schizosaccharomyces pombe, Caenorhabditis elegans, mouse and man. The
characteristic RFX DNA binding motif has been recruited into otherwise very
divergent regulatory factors functioning in a diverse spectrum of unrelated
systems, including regulation of the mitotic cell cycle in fission yeast,
the control of the immune response in mammals, and infection by human
hepatitis B virus.
ARTICLES
RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom
Department of Genetics and Microbiology, University of Geneva Medical School, Centre Medical Universtaire, Switzerland.
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