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Nucleic Acids Research, Vol 24, Issue 5 854-858, Copyright © 1996 by Oxford University Press

ARTICLES

The P9.1-P9.2 peripheral extension helps guide folding of the Tetrahymena ribozyme

PP Zarrinkar and JR Williamson
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

We have previously proposed a hierarchical model for the folding mechanism of the Tetrahymena ribozyme that may illustrate general features of the folding pathways of large RNAs. While the role of elements in the conserved catalytic core of this ribozyme during the folding process is beginning to emerge, the participation of non- conserved peripheral extensions in the kinetic folding mechanism has not yet been addressed. We now show that the 3'-terminal P9.1-P9.2 extension of the Tetrahymena ribozyme plays an important role during the folding process and appears to guide formation of the catalytic core.
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