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Nucleic Acids Research, Vol 24, Issue 5 938-942, Copyright © 1996 by Oxford University Press

ARTICLES

Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells

Y Ohta, H Kijima, T Ohkawa, M Kashani-Sabet and KJ Scanlon
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.

In this study, we have compared the efficacy of a tissue-specific promoter (tyrosinase promoter) with a viral promoter to express anti- ras ribozyme RNA in human melanoma cells. The retroviral vector containing the tyrosinase promoter was superior in its ability to suppress the human melanoma phenotype in vitro as characterized by changes in growth, melanin synthesis, morphology and H-ras gene expression. These data support the use of tissue-specific expression of anti-oncogene ribozymes as a rational therapeutic strategy in human cancers.
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