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Nucleic Acids Research, Vol 24, Issue 6 995-999, Copyright © 1996 by Oxford University Press

ARTICLES

A molecular clock based on the expansion of gene families

YA Trusov and PH Dear
Institute of Cytology and Genetics, Siberian Branch of Academy of Sciences, Russia.

There is evidence to suggest that eukaryotic genomes are subject to frequent insertions and deletions of non-coding DNA. This may lead to a gradual increase or decrease in genome size, or to a dynamic equilibrium in which the overall size remains constant. We argue, however, that there is a bias favouring an accumulation of non-coding DNA in the proximity of genes. Such bias causes a progressive change in genome structure regardless of whether the overall genome size increases, decreases or remains constant. We show that this change may serve as a 'molecular clock', supplementing that provided by nucleotide substitution rates.
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