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Nucleic Acids Research, Vol 24, Issue 7 1187-1194, Copyright © 1996 by Oxford University Press

ARTICLES

The use of non-uniform deuterium labelling ['NMR-window'] to study the NMR structure of a 21mer RNA hairpin

A Foldesi, SI Yamakage, FP Nilsson, TV Maltseva and J Chattopadhyaya
Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Sweden.

The first synthesis of a non-uniformly deuterium labelled 21mer RNA is reported using our 'NMR-window' concept, showing its unique application in the unambiguous NMR assignment of the non-exchangeable aromatic and sugar protons.
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