Nucleic Acids Research, Vol 24, Issue 7 1220-1224, Copyright © 1996 by Oxford University Press
BC Valdez, D Henning, RK Busch, K Woods, H Flores-Rozas, J Hurwitz, L Perlaky and H Busch
Watermelon stomach is characterized by prominent stripes of ectatic
vascular tissue in the stomach similar to stripes on a watermelon; in
patients with this disorder chronic gastrointestinal bleeding occurs and
approximately half of these patients have associated autoimmune disorders.
In the serum of one patient, an antinucleolar antibody titer of 1:25 600
was found; the antibodies specifically recognized an approximately 100 kDa
nucleolar protein, which we referred to as the 'Gu' protein. Its cDNA was
cloned and sequenced. The Gu protein is a member of a new subgroup of RNA
helicases, the DEXD box family. Gu protein fused with glutathione
S-transferase contains ATP-dependent RNA helicase activity which preferably
translocates in the 5'-->3' direction. Its RNA folding activity,
RNA-dependent ATPase and dATPase activities, and its translocation
direction are similar to those of RNA helicase II [Flores-Rozas, H. and
Hurwitz, J. (1993) J. Biol. Chem. 268, 21372-21383]. Sequencing of 209
amino acids of RNA helicase II peptides showed 96.7% identity with the
cDNA-derived amino acid sequence of the Gu protein. The precise biological
roles of this RNA helicase in the biogenesis of ribosomal RNA and the
pathogenesis of watermelon disease and autoimmune disorder require further
study.
ARTICLES
A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.
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