Nucleic Acids Research, Vol 24, Issue 9 1589-1593, Copyright © 1996 by Oxford University Press
MC Hollander, I Alamo and AJ Fornace Jr
gadd7 cDNA was isolated from Chinese hamster ovary (CHO) cells on the basis
of increased levels of RNA following treatment with UV radiation. The
transcript for gadd7, as well as for four other gadd genes, was found to
increase rapidly and coordinately following several different types of DNA
damage and more slowly following other stresses that elicit growth arrest.
Agents that induce gadd7 RNA include alkylating agents, such as methyl
methanesulfonate (MMS), N-methyl-N'-nitro-N- nitrosoguanidine (MNNG) and
mechlorethamine HCl (HN2), oxidizing agents, such as hydrogen peroxide, and
growth arrest signals, such as medium depletion (starvation). Since growth
arrest is a cellular consequence of many types of DNA damage in normal
cells, it was thought that gadd7 may play a role in the cellular response
to DNA damage. Indeed, overexpression of gadd7 led to a decrease in cell
growth. Interestingly, gadd7 cDNA does not contain an appreciable open
reading frame and does not appear to encode a protein product, but instead
may function at the RNA level.
ARTICLES
A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product
Laboratory of Molecular Pharmacology, Division of Basic Science, National Cancer Institute, Bethesda, MD 20892, USA.
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