Nucleic Acids Research, Vol 25, Issue 1 206-211, Copyright © 1997 by Oxford University Press
V Giudicelli, D Chaume, J Bodmer, W Muller, C Busin, S Marsh, R Bontrop, L Marc, A Malik and MP Lefranc
IMGT, the international ImMunoGeneTics database, is an integrated database
specializing in immunoglobulins, T-cell receptors (TcR) and major
histocompatibility complex (MHC) of all vertebrate species, initiated and
co-ordinated by Marie-Paule Lefranc, CNRS, Montpellier II University,
Montpellier, France (lefranc@ligm.crbm.cnrs-mop.fr). IMGT includes two
databases: LIGM-DB (for immunoglobulins and TcR) and MHC/HLA-DB. IMGT
comprises expertly annotated sequences and alignment tables. LIGM-DB
contains more than 19 000 immunoglobulin and TcR sequences from 78 species.
MHC/HLA-DB contains class I and class II human leukocyte antigen alignment
tables. An IMGT tool, DNAPLOT, developed for immunoglobulins, TcR and MHC
sequence alignments, is also available. IMGT works in close collaboration
with the EMBL database. IMGT goals are to establish a common data access to
all immunogenetics data, including sequences, oligonucleotide primers, gene
maps and other genetic data of immunoglobulins, TcR and MHC molecules, and
to provide a graphical user-friendly data access. IMGT will have important
implications in medical research (repertoire in autoimmune diseases, AIDS,
leukemias, lymphomas), therapeutical approaches (antibody engineering),
genome diversity and genome evolution studies. IMGT can be accessed at
http://imgt.cnusc.fr:8104 and http://www.ebi.ac.uk/IMGT
ARTICLES
IMGT, the international ImMunoGeneTics database
Laboratoire d'ImmunoGenetique Moleculaire, LIGM, UMR CNRS 5535, BP5051, 1919 route de Mende, 34033 Montpellier Cedex 1, France.
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