Nucleic Acids Research, Vol 25, Issue 1 212-217, Copyright © 1997 by Oxford University Press
TK Attwood, ME Beck, AJ Bleasby, K Degtyarenko, AD Michie and DJ Parry-Smith
The PRINTS database of protein family 'fingerprints' is a diagnostic
resource that complements the PROSITE dictionary of sites and patterns.
Unlike regular expressions, fingerprints exploit groups of conserved motifs
within sequence alignments to build characteristic signatures of family
membership. Thus fingerprints inherently offer improved diagnostic
reliability by virtue of the mutual context provided by motif neighbours.
To date, 600 fingerprints have been constructed and stored in PRINTS,
representing a 50% increase in the size of the database in the last year.
The current version, 13.0, encodes approximately 3000 motifs, covering a
range of globular and membrane proteins, modular polypeptides, and so on.
The database is accessible via UCL's Bioinformatics World Wide Web (WWW)
server at http://www.biochem.ucl.ac.uk/bsm/dbbrowser / . We describe here
progress with the database, its Web interface, and a recent exciting
development: the integration of a novel colour alignment editor
(http://www.biochem.ucl.ac.uk/bsm/dbbrowser++ +/CINEMA ), which allows
visualisation and interactive manipulation of PRINTS alignments over the
Internet.
ARTICLES
Novel developments with the PRINTS protein fingerprint database
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WCIE 6BT, UK. attwood@bsm.bioc.ucl.ac.uk
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