Nucleic Acids Research, Vol 25, Issue 13 2547-2561, Copyright © 1997 by Oxford University Press
G Edwalds-Gilbert, KL Veraldi and C Milcarek
Many genes have been described and characterized which result in
alternative polyadenylation site use at the 3'-end of their mRNAs based on
the cellular environment. In this survey and summary article 95 genes are
discussed in which alternative polyadenylation is a consequence of tandem
arrays of poly(A) signals within a single 3'- untranslated region. An
additional 31 genes are described in which polyadenylation at a
promoter-proximal site competes with a splicing reaction to influence
expression of multiple mRNAs. Some have a composite internal/terminal exon
which can be differentially processed. Others contain alternative
3'-terminal exons, the first of which can be skipped in some cells. In some
cases the mRNAs formed from these three classes of genes are differentially
processed from the primary transcript during the cell cycle or in a
tissue-specific or developmentally specific pattern. Immunoglobulin heavy
chain genes have composite exons; regulated production of two different Ig
mRNAs has been shown to involve B cell stage-specific changes in trans
-acting factors involved in formation of the active polyadenylation
complex. Changes in the activity of some of these same factors occur during
viral infection and take-over of the cellular machinery, suggesting the
potential applicability of at least some aspects of the Ig model. The
differential expression of a number of genes that undergo alternative
poly(A) site choice or polyadenylation/splicing competition could be
regulated at the level of amounts and activities of either generic or
tissue-specific polyadenylation factors and/or splicing factors.
REVIEWS
Alternative poly(A) site selection in complex transcription units: means to an end?
Department of Molecular Genetics and Biochemistry and the Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261-2072, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  V. Anquetil, C. Le Sommer, A. Mereau, S. Hamon, H. Lerivray, and S. Hardy Polypyrimidine Tract Binding Protein Prevents Activity of an Intronic Regulatory Element That Promotes Usage of a Composite 3'-Terminal Exon J. Biol. Chem., November 20, 2009; 284(47): 32370 - 32383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Shears Diphosphoinositol Polyphosphates: Metabolic Messengers? Mol. Pharmacol., August 1, 2009; 76(2): 236 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Evans, M. A. Connor, L. D. Moss, S. Lackay, J. H. Leary III, T. Krunkosky, and L. Jaso-Friedmann Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor J. Leukoc. Biol., July 1, 2009; 86(1): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Al-Ahmadi, M. Al-Ghamdi, L. Al-Haj, M. Al-Saif, and K. S. A. Khabar Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation Nucleic Acids Res., June 1, 2009; 37(11): 3612 - 3624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Ji, J. Y. Lee, Z. Pan, B. Jiang, and B. Tian Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development PNAS, April 28, 2009; 106(17): 7028 - 7033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ghosh, K. Soni, V. Scaria, M. Halimani, C. Bhattacharjee, and B. Pillai MicroRNA-mediated up-regulation of an alternatively polyadenylated variant of the mouse cytoplasmic {beta}-actin gene Nucleic Acids Res., November 1, 2008; 36(19): 6318 - 6332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Liu, D. T. Fritz, M. B. Rogers, and A. J. Shatkin Species-specific cis-Regulatory Elements in the 3'-Untranslated Region Direct Alternative Polyadenylation of Bone Morphogenetic Protein 2 mRNA J. Biol. Chem., October 17, 2008; 283(42): 28010 - 28019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Lee, Z. Ji, and B. Tian Phylogenetic analysis of mRNA polyadenylation sites reveals a role of transposable elements in evolution of the 3'-end of genes Nucleic Acids Res., October 1, 2008; 36(17): 5581 - 5590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. W. To, Z. Zhan, T. Litman, and S. E. Bates Regulation of ABCG2 Expression at the 3' Untranslated Region of Its mRNA through Modulation of Transcript Stability and Protein Translation by a Putative MicroRNA in the S1 Colon Cancer Cell Line Mol. Cell. Biol., September 1, 2008; 28(17): 5147 - 5161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sandberg, J. R. Neilson, A. Sarma, P. A. Sharp, and C. B. Burge Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites Science, June 20, 2008; 320(5883): 1643 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kerr, M. Alvarez-Saavedra, M. A. Saez, A. Saona, and J. I. Young Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice Hum. Mol. Genet., June 15, 2008; 17(12): 1707 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Sartini, H. Wang, W. Wang, C. F. Millette, and D. L. Kilpatrick Pre-Messenger RNA Cleavage Factor I (CFIm): Potential Role in Alternative Polyadenylation During Spermatogenesis Biol Reprod, March 1, 2008; 78(3): 472 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Akimitsu Messenger RNA Surveillance Systems Monitoring Proper Translation Termination J. Biochem., January 1, 2008; 143(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dass, S. Tardif, J. Y. Park, B. Tian, H. M. Weitlauf, R. A. Hess, K. Carnes, M. D. Griswold, C. L. Small, and C. C. MacDonald Loss of polyadenylation protein {tau}CstF-64 causes spermatogenic defects and male infertility PNAS, December 18, 2007; 104(51): 20374 - 20379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Shell, K. Martincic, J. Tran, and C. Milcarek Increased Phosphorylation of the Carboxyl-Terminal Domain of RNA Polymerase II and Loading of Polyadenylation and Cotranscriptional Factors Contribute to Regulation of the Ig Heavy Chain mRNA in Plasma Cells J. Immunol., December 1, 2007; 179(11): 7663 - 7673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Loudig, E. Milova, M. Brandwein-Gensler, A. Massimi, T. J. Belbin, G. Childs, R. H. Singer, T. Rohan, and M. B. Prystowsky Molecular restoration of archived transcriptional profiles by complementary-template reverse-transcription (CT-RT) Nucleic Acids Res., August 1, 2007; 35(15): e94 - e94. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Isken and L. E. Maquat Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function Genes & Dev., August 1, 2007; 21(15): 1833 - 3856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hall-Pogar, S. Liang, L. K. Hague, and C. S. Lutz Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR RNA, July 1, 2007; 13(7): 1103 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hellquist, M. Zucchelli, K. Kivinen, U. Saarialho-Kere, S. Koskenmies, E. Widen, H. Julkunen, A. Wong, M.-L. Karjalainen-Lindsberg, T. Skoog, et al. The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus J. Med. Genet., May 1, 2007; 44(5): 314 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. P. Ivanov and J. F. Atkins Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation Nucleic Acids Res., March 19, 2007; 35(6): 1842 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Moucadel, F. Lopez, T. Ara, P. Benech, and D. Gautheret Beyond the 3' end: experimental validation of extended transcript isoforms Nucleic Acids Res., March 19, 2007; 35(6): 1947 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rouhana and M. Wickens Autoregulation of GLD-2 cytoplasmic poly(A) polymerase RNA, February 1, 2007; 13(2): 188 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Tian, Z. Pan, and J. Y. Lee Widespread mRNA polyadenylation events in introns indicate dynamic interplay between polyadenylation and splicing Genome Res., February 1, 2007; 17(2): 156 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Liu, J. M. Brockman, B. Dass, L. N. Hutchins, P. Singh, J. R. McCarrey, C. C. MacDonald, and J. H. Graber Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis Nucleic Acids Res., January 12, 2007; 35(1): 234 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Lee, I. Yeh, J. Y. Park, and B. Tian PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes Nucleic Acids Res., January 12, 2007; 35(suppl_1): D165 - D168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Duan and C. R Jefcoate The predominant cAMP-stimulated 3.5 kb StAR mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability J. Mol. Endocrinol., January 1, 2007; 38(1): 159 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubo, T. Wada, Y. Yamaguchi, A. Shimizu, and H. Handa Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs Nucleic Acids Res., December 4, 2006; 34(21): 6264 - 6271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Gagnon, C. M. Longo-Guess, M. Berryman, J.-B. Shin, K. W. Saylor, H. Yu, P. G. Gillespie, and K. R. Johnson The Chloride Intracellular Channel Protein CLIC5 Is Expressed at High Levels in Hair Cell Stereocilia and Is Essential for Normal Inner Ear Function J. Neurosci., October 4, 2006; 26(40): 10188 - 10198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Wilusz and K. L. Beemon The Negative Regulator of Splicing Element of Rous Sarcoma Virus Promotes Polyadenylation J. Virol., October 1, 2006; 80(19): 9634 - 9640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lopez, S. Granjeaud, T. Ara, B. Ghattas, and D. Gautheret The disparate nature of "intergenic" polyadenylation sites RNA, October 1, 2006; 12(10): 1794 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Peterson, G. L. Bingham, and C. Cowan Multiple features contribute to the use of the immunoglobulin m secretion-specific poly(a) signal but are not required for developmental regulation. Mol. Cell. Biol., September 1, 2006; 26(18): 6762 - 6771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Berlanga, A. Baass, and N. Sonenberg Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B RNA, August 1, 2006; 12(8): 1556 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Temple, P. Lamesch, S. Milstein, D. E. Hill, L. Wagner, T. Moore, and M. Vidal From genome to proteome: developing expression clone resources for the human genome. Hum. Mol. Genet., April 15, 2006; 15(suppl_1): R31 - R43. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Shah and P. Bork LSAT: learning about alternative transcripts in MEDLINE Bioinformatics, April 1, 2006; 22(7): 857 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Unwalla, H.-T. Li, I. Bahner, M.-J. Li, D. Kohn, and J. J. Rossi Novel Pol II Fusion Promoter Directs Human Immunodeficiency Virus Type 1-Inducible Coexpression of a Short Hairpin RNA and Protein J. Virol., February 15, 2006; 80(4): 1863 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Shell, C. Hesse, S. M. Morris Jr., and C. Milcarek Elevated Levels of the 64-kDa Cleavage Stimulatory Factor (CstF-64) in Lipopolysaccharide-stimulated Macrophages Influence Gene Expression and Induce Alternative Poly(A) Site Selection J. Biol. Chem., December 2, 2005; 280(48): 39950 - 39961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Milligan, C. Torchet, C. Allmang, T. Shipman, and D. Tollervey A Nuclear Surveillance Pathway for mRNAs with Defective Polyadenylation Mol. Cell. Biol., November 15, 2005; 25(22): 9996 - 10004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Gilmartin Eukaryotic mRNA 3' processing: a common means to different ends Genes & Dev., November 1, 2005; 19(21): 2517 - 2521. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Brockman, P. Singh, D. Liu, S. Quinlan, J. Salisbury, and J. H. Graber PACdb: PolyA Cleavage Site and 3'-UTR Database Bioinformatics, September 15, 2005; 21(18): 3691 - 3693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bego, J. Maciejewski, S. Khaiboullina, G. Pari, and S. St. Jeor Characterization of an Antisense Transcript Spanning the UL81-82 Locus of Human Cytomegalovirus J. Virol., September 1, 2005; 79(17): 11022 - 11034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. R. Henderson, F. Liu, S. Drea, G. G. Simpson, and C. Dean An allelic series reveals essential roles for FY in plant development in addition to flowering-time control Development, August 15, 2005; 132(16): 3597 - 3607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Venkataraman, K. M. Brown, and G. M. Gilmartin Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition Genes & Dev., June 1, 2005; 19(11): 1315 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yan and T. G. Marr Computational analysis of 3'-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat Genome Res., March 1, 2005; 15(3): 369 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tian, J. Hu, H. Zhang, and C. S. Lutz A large-scale analysis of mRNA polyadenylation of human and mouse genes Nucleic Acids Res., January 12, 2005; 33(1): 201 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, J. Hu, M. Recce, and B. Tian PolyA_DB: a database for mammalian mRNA polyadenylation Nucleic Acids Res., January 1, 2005; 33(suppl_1): D116 - D120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Fritz, D. Liu, J. Xu, S. Jiang, and M. B. Rogers Conservation of Bmp2 Post-transcriptional Regulatory Mechanisms J. Biol. Chem., November 19, 2004; 279(47): 48950 - 48958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Druker, T. J. Bruxner, N. J. Lehrbach, and E. Whitelaw Complex patterns of transcription at the insertion site of a retrotransposon in the mouse Nucleic Acids Res., November 1, 2004; 32(19): 5800 - 5808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Gunther and D. L. Riddle Alternative Polyadenylation Results in a Truncated daf-4 BMP Receptor That Antagonizes DAF-7-mediated Development in Caenorhabditis elegans J. Biol. Chem., September 17, 2004; 279(38): 39555 - 39564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Phillips, N. Pachikara, and S. I. Gunderson U1A Inhibits Cleavage at the Immunoglobulin M Heavy-Chain Secretory Poly(A) Site by Binding between the Two Downstream GU-Rich Regions Mol. Cell. Biol., July 15, 2004; 24(14): 6162 - 6171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Danckwardt, N. H. Gehring, G. Neu-Yilik, P. Hundsdoerfer, M. Pforsich, U. Frede, M. W. Hentze, and A. E. Kulozik The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations Blood, July 15, 2004; 104(2): 428 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cao, M. Xiao, F. Sun, X. Xiao, W. Pei, J. Li, S. H. Graham, R. P. Simon, and J. Chen Cloning of a Novel Apaf-1-Interacting Protein: A Potent Suppressor of Apoptosis and Ischemic Neuronal Cell Death J. Neurosci., July 7, 2004; 24(27): 6189 - 6201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hamon, C. Le Sommer, A. Mereau, M.-R. Allo, and S. Hardy Polypyrimidine Tract-binding Protein Is Involved in Vivo in Repression of a Composite Internal/3' -Terminal Exon of the Xenopus {alpha}-Tropomyosin Pre-mRNA J. Biol. Chem., May 21, 2004; 279(21): 22166 - 22175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sciammas and M. M. Davis Modular Nature of Blimp-1 in the Regulation of Gene Expression during B Cell Maturation J. Immunol., May 1, 2004; 172(9): 5427 - 5440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Wallace, T. L. Denison, E. N. Attaya, and C. C. MacDonald Developmental Distribution of the Polyadenylation Protein CstF-64 and the Variant {tau}CstF-64 in Mouse and Rat Testis Biol Reprod, April 1, 2004; 70(4): 1080 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Akgul and C.-P. D. Tu Pentobarbital-mediated Regulation of Alternative Polyadenylation in Drosophila Glutathione S-Transferase D21 mRNAs J. Biol. Chem., February 6, 2004; 279(6): 4027 - 4033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Qiu, R. Nayak, and D. J. Pintel Alternative Polyadenylation of Adeno-Associated Virus Type 5 RNA within an Internal Intron Is Governed by both a Downstream Element within the Intron 3' Splice Acceptor and an Element Upstream of the P41 Initiation Site J. Virol., January 1, 2004; 78(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nagashima, H. Matsuda, D. G. Silva, N. Petrovsky, RIKEN GER Group, GSL Members, A. Konagaya, and C. Schonbach FREP: a database of functional repeats in mouse cDNAs Nucleic Acids Res., January 1, 2004; 32(90001): D471 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cui and C. L. Denis In Vivo Evidence that Defects in the Transcriptional Elongation Factors RPB2, TFIIS, and SPT5 Enhance Upstream Poly(A) Site Utilization Mol. Cell. Biol., November 1, 2003; 23(21): 7887 - 7901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. BRUCE, R.W. C. DINGLE, and M. L. PETERSON B-cell and plasma-cell splicing differences: A potential role in regulated immunoglobulin RNA processing RNA, October 1, 2003; 9(10): 1264 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fortes, Y. Cuevas, F. Guan, P. Liu, S. Pentlicky, S. P. Jung, M. L. Martinez-Chantar, J. Prieto, D. Rowe, and S. I. Gunderson Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA PNAS, July 8, 2003; 100(14): 8264 - 8269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Beck, K. Hayashi, B. Nishiguchi, O. Le Saux, M. Hayashi, and C. D. Boyd The Distribution of Abcc6 in Normal Mouse Tissues Suggests Multiple Functions for this ABC Transporter J. Histochem. Cytochem., July 1, 2003; 51(7): 887 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Phillips and S. Gunderson Sequences Adjacent to the 5' Splice Site Control U1A Binding Upstream of the IgM Heavy Chain Secretory Poly(A) Site J. Biol. Chem., June 6, 2003; 278(24): 22102 - 22111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lopez-Camarillo, J. P. Luna-Arias, L. A. Marchat, and E. Orozco EhPgp5 mRNA Stability Is a Regulatory Event in the Entamoeba histolytica Multidrug Resistance Phenotype J. Biol. Chem., March 21, 2003; 278(13): 11273 - 11280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tacahashi, S. Helmling, and C. L. Moore Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor Nucleic Acids Res., March 15, 2003; 31(6): 1744 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Zarudnaya, I. M. Kolomiets, A. L. Potyahaylo, and D. M. Hovorun Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures Nucleic Acids Res., March 1, 2003; 31(5): 1375 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hermey, S. J. Keat, P. Madsen, C. Jacobsen, C. M. Petersen, and J. Gliemann Characterization of sorCS1, an Alternatively Spliced Receptor with Completely Different Cytoplasmic Domains That Mediate Different Trafficking in Cells J. Biol. Chem., February 21, 2003; 278(9): 7390 - 7396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Natalizio, L. C. Muniz, G. K. Arhin, J. Wilusz, and C. S. Lutz Upstream Elements Present in the 3'-Untranslated Region of Collagen Genes Influence the Processing Efficiency of Overlapping Polyadenylation Signals J. Biol. Chem., November 1, 2002; 277(45): 42733 - 42740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Hu, J. Bi, H. H. Loh, and L.-N. Wei Regulation of Mouse kappa Opioid Receptor Gene Expression by Different 3'-Untranslated Regions and the Effect of Retinoic Acid Mol. Pharmacol., October 1, 2002; 62(4): 881 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aissouni, C. Perez, B. Calmels, and P. D. Benech The Cleavage/Polyadenylation Activity Triggered by a U-rich Motif Sequence Is Differently Required Depending on the Poly(A) Site Location at Either the First or Last 3'-Terminal Exon of the 2'-5' Oligo(A) Synthetase Gene J. Biol. Chem., September 20, 2002; 277(39): 35808 - 35814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Osato, M. Itoh, H. Konno, S. Kondo, K. Shibata, P. Carninci, T. Shiraki, A. Shinagawa, T. Arakawa, S. Kikuchi, et al. A Computer-Based Method of Selecting Clones for a Full-Length cDNA Project: Simultaneous Collection of Negligibly Redundant and Variant cDNAs Genome Res., July 1, 2002; 12(7): 1127 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. van Dooren, V. Su, M. C. D'Ombrain, and G. I. McFadden Processing of an Apicoplast Leader Sequence in Plasmodium falciparum and the Identification of a Putative Leader Cleavage Enzyme J. Biol. Chem., June 21, 2002; 277(26): 23612 - 23619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Arhin, M. Boots, P. S. Bagga, C. Milcarek, and J. Wilusz Downstream sequence elements with different affinities for the hnRNP H/H' protein influence the processing efficiency of mammalian polyadenylation signals Nucleic Acids Res., April 15, 2002; 30(8): 1842 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fujino, A. Suzuki, Y. Ito, K. Ohyashiki, Y. Hatano, I. Miura, and T. Nakamura Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15) Blood, February 15, 2002; 99(4): 1428 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bottai, J. F. Guzowski, M. K. Schwarz, S. H. Kang, B. Xiao, A. Lanahan, P. F. Worley, and P. H. Seeburg Synaptic Activity-Induced Conversion of Intronic to Exonic Sequence in Homer 1 Immediate Early Gene Expression J. Neurosci., January 1, 2002; 22(1): 167 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gross and C. L. Moore Rna15 Interaction with the A-Rich Yeast Polyadenylation Signal Is an Essential Step in mRNA 3'-End Formation Mol. Cell. Biol., December 1, 2001; 21(23): 8045 - 8055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ahuja, D. S. Karow, J. E. Kilpatrick, and M. J. Imperiale RNA Polymerase II-dependent Positional Effects on mRNA 3' End Processing in the Adenovirus Major Late Transcription Unit J. Biol. Chem., November 2, 2001; 276(45): 41825 - 41831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Strausberg and G. J. Riggins Navigating the human transcriptome PNAS, October 9, 2001; 98(21): 11837 - 11838. [Full Text] [PDF]
|
|
|
|
|
|
L. Queimado, M. Rao, R. A. Schultz, E. V. Koonin, L. Aravind, T. Nardo, M. Stefanini, and E. C. Friedberg Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant Nucleic Acids Res., May 1, 2001; 29(9): 1884 - 1891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Pauws, A. H. C. van Kampen, S. A. R. van de Graaf, J. J. M. de Vijlder, and C. Ris-Stalpers Heterogeneity in polyadenylation cleavage sites in mammalian mRNA sequences: implications for SAGE analysis Nucleic Acids Res., April 15, 2001; 29(8): 1690 - 1694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Vickers, J. R. Wyatt, T. Burckin, C. F. Bennett, and S. M. Freier Fully modified 2' MOE oligonucleotides redirect polyadenylation Nucleic Acids Res., March 15, 2001; 29(6): 1293 - 1299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Wilson, C. Riemer, D. W. Martindale, P. Schnupf, A. P. Boright, T. L. Cheung, D. M. Hardy, S. Schwartz, S. W. Scherer, L.-C. Tsui, et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 Nucleic Acids Res., March 15, 2001; 29(6): 1352 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Veraldi, G. K. Arhin, K. Martincic, L.-H. Chung-Ganster, J. Wilusz, and C. Milcarek hnRNP F Influences Binding of a 64-Kilodalton Subunit of Cleavage Stimulation Factor to mRNA Precursors in Mouse B Cells Mol. Cell. Biol., February 15, 2001; 21(4): 1228 - 1238. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. KARNOWSKI, P. YU, G. ACHATZ, and M. C. LAMERS The Road to the Production of IgE Is Long and Winding Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): S71 - 75. [Full Text] [PDF]
|
|
|
|
|
|
E. G. M. Mbella, S. Bertrand, G. Huez, and J.-N. Octave A GG Nucleotide Sequence of the 3' Untranslated Region of Amyloid Precursor Protein mRNA Plays a Key Role in the Regulation of Translation and the Binding of Proteins Mol. Cell. Biol., July 1, 2000; 20(13): 4572 - 4579. [Abstract] [Full Text]
|
|
|
|
|
|
E. Beaudoing, S. Freier, J. R. Wyatt, J.-M. Claverie, and D. Gautheret Patterns of Variant Polyadenylation Signal Usage in Human Genes Genome Res., July 1, 2000; 10(7): 1001 - 1010. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Caffrey, S. T. Safrany, X. Yang, and S. B. Shears Discovery of Molecular and Catalytic Diversity among Human Diphosphoinositol-Polyphosphate Phosphohydrolases. AN EXPANDING NUDT FAMILY J. Biol. Chem., April 21, 2000; 275(17): 12730 - 12736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Garcia, M. Salanoubat, N. Choisne, and A. Tissier An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis Nucleic Acids Res., April 15, 2000; 28(8): 1692 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Shehin, R. O. Stephenson, and W. F. Greenlee Transcriptional Regulation of the Human CYP1B1 Gene. EVIDENCE FOR INVOLVEMENT OF AN ARYL HYDROCARBON RECEPTOR RESPONSE ELEMENT IN CONSTITUTIVE EXPRESSION J. Biol. Chem., March 15, 2000; 275(10): 6770 - 6776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Chew, L. Baginsky, and I. C. Eperon An exonic splicing silencer in the testes-specific DNA ligase III {beta} exon Nucleic Acids Res., January 15, 2000; 28(2): 402 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hornsten, C. Su, A. E. Osbourn, P. Garosi, U. Hellman, C. Wernstedt, and E. H. Oliw Cloning of Linoleate Diol Synthase Reveals Homology with Prostaglandin H Synthases J. Biol. Chem., October 1, 1999; 274(40): 28219 - 28224. [Abstract] [Full Text] [PDF]
|
|