Nucleic Acids Research, Vol 25, Issue 13 2595-2597, Copyright © 1997 by Oxford University Press
NW Kim and F Wu
The telomeric repeat amplification protocol (TRAP) assay has been used to
test telomerase activity in numerous cancer specimens. We describe primers,
controls and quantification methods for the TRAP assay to accurately
measure the level of telomerase activity in clinical samples. The assay is
reliable and reproducible in routine analyses and can be used to estimate
the processivity of telomerase activity.
ARTICLES
Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)
Geron Corporation, Menlo Park, CA 94025, USA. nkim@geron.com
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M. Majka, A. Janowska-Wieczorek, J. Ratajczak, M. A. Kowalska, G. Vilaire, Z. K. Pan, M. Honczarenko, L. A. Marquez, M. Poncz, and M. Z. Ratajczak Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis Blood, December 15, 2000; 96(13): 4142 - 4151. [Abstract] [Full Text] [PDF] |
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J. B. de Kok, M. R. van Balken, R. W.H.M. Roelofs, Y. A.W.G. van Aarssen, D. W. Swinkels, and J. M.T. Klein Gunnewiek Quantification of hTERT mRNA and Telomerase Activity in Bladder Washings of Patients with Recurrent Urothelial Cell Carcinomas Clin. Chem., December 1, 2000; 46(12): 2003 - 2007. [Full Text] [PDF] |
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J. Okabe, A. Eguchi, A. Masago, T. Hayakawa, and M. Nakanishi TRF1 is a critical trans-acting factor required for de novo telomere formation in human cells Hum. Mol. Genet., November 1, 2000; 9(18): 2639 - 2650. [Abstract] [Full Text] [PDF] |
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M. Migliaccio, M. Amacker, T. Just, P. Reichenbach, D. Valmori, J.-C. Cerottini, P. Romero, and M. Nabholz Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte Immortalization J. Immunol., November 1, 2000; 165(9): 4978 - 4984. [Abstract] [Full Text] [PDF] |
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N. H. Son, S. Murray, J. Yanovski, R. J. Hodes, and N.-p. Weng Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age J. Immunol., August 1, 2000; 165(3): 1191 - 1196. [Abstract] [Full Text] [PDF] |
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Q.-X. Li, J. M. Robbins, P. J. Welch, F. Wong-Staal, and J. R. Barber A novel functional genomics approach identifies mTERT as a suppressor of fibroblast transformation Nucleic Acids Res., July 1, 2000; 28(13): 2605 - 2612. [Abstract] [Full Text] [PDF] |
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S. Misiti, S. Nanni, G. Fontemaggi, Y.-S. Cong, J. Wen, H. W. Hirte, G. Piaggio, A. Sacchi, A. Pontecorvi, S. Bacchetti, et al. Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells Mol. Cell. Biol., June 1, 2000; 20(11): 3764 - 3771. [Abstract] [Full Text] |
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E. Dellambra, O. Golisano, S. Bondanza, E. Siviero, P. Lacal, M. Molinari, S. D'Atri, and M. De Luca Downregulation of 14-3-3{sigma} Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes J. Cell Biol., May 29, 2000; 149(5): 1117 - 1130. [Abstract] [Full Text] [PDF] |
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S. Le, R. Sternglanz, and C. W. Greider Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA Mol. Biol. Cell, March 1, 2000; 11(3): 999 - 1010. [Abstract] [Full Text] |
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M. A. Dickson, W. C. Hahn, Y. Ino, V. Ronfard, J. Y. Wu, R. A. Weinberg, D. N. Louis, F. P. Li, and J. G. Rheinwald Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics Mol. Cell. Biol., February 15, 2000; 20(4): 1436 - 1447. [Abstract] [Full Text] |
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S. K. Dessain, H.-y. Yu, R. R. Reddel, R. L. Beijersbergen, and R. A. Weinberg Methylation of the Human Telomerase Gene CpG Island Cancer Res., February 1, 2000; 60(3): 537 - 541. [Abstract] [Full Text] |
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M. Engelhardt, K. Mackenzie, P. Drullinsky, R. T. Silver, and M. A. S. Moore Telomerase Activity and Telomere Length in Acute and Chronic Leukemia, Pre- and Post-ex Vivo Culture Cancer Res., February 1, 2000; 60(3): 610 - 617. [Abstract] [Full Text] |
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F. Bachand and C. Autexier Functional Reconstitution of Human Telomerase Expressed in Saccharomyces cerevisiae J. Biol. Chem., December 31, 1999; 274(53): 38027 - 38031. [Abstract] [Full Text] [PDF] |
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L. A. Carey, N. W. Kim, S. Goodman, J. Marks, G. Henderson, C. B. Umbricht, J. S. Dome, W. Dooley, S. R. Amshey, and S. Sukumar Telomerase Activity and Prognosis in Primary Breast Cancers J. Clin. Oncol., October 1, 1999; 17(10): 3075 - 3081. [Abstract] [Full Text] [PDF] |
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J. Yang, E. Chang, A. M. Cherry, C. D. Bangs, Y. Oei, A. Bodnar, A. Bronstein, C.-P. Chiu, and G. S. Herron Human Endothelial Cell Life Extension by Telomerase Expression J. Biol. Chem., September 10, 1999; 274(37): 26141 - 26148. [Abstract] [Full Text] [PDF] |
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J. S. Dome, S. Chung, T. Bergemann, C. B. Umbricht, M. Saji, L. A. Carey, P. E. Grundy, E. J. Perlman, N. E. Breslow, and S. Sukumar High Telomerase Reverse Transcriptase (hTERT) Messenger RNA Level Correlates with Tumor Recurrence in Patients with Favorable Histology Wilms' Tumor Cancer Res., September 1, 1999; 59(17): 4301 - 4307. [Abstract] [Full Text] [PDF] |
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P. Tangkijvanich, D. Tresukosol, P. Sampatanukul, S. Sakdikul, N. Voravud, V. Mahachai, and A. Mutirangura Telomerase Assay for Differentiating between Malignancy-related and Nonmalignant Ascites Clin. Cancer Res., September 1, 1999; 5(9): 2470 - 2475. [Abstract] [Full Text] [PDF] |
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J. Albanell, G. J. Bosl, V. E. Reuter, M. Engelhardt, S. Franco, M. A. S. Moore, and E. Dmitrovsky Telomerase Activity in Germ Cell Cancers and Mature Teratomas J Natl Cancer Inst, August 4, 1999; 91(15): 1321 - 1326. [Abstract] [Full Text] [PDF] |
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P. Yan, J.-M. Coindre, J. Benhattar, F. T. Bosman, and L. Guillou Telomerase Activity and Human Telomerase Reverse Transcriptase mRNA Expression in Soft Tissue Tumors: Correlation with Grade, Histology, and Proliferative Activity Cancer Res., July 1, 1999; 59(13): 3166 - 3170. [Abstract] [Full Text] [PDF] |
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M. Saji, S. Xydas, W. H. Westra, C.-K. Liang, D. P. Clark, R. Udelsman, C. B. Umbricht, S. Sukumar, and M. A. Zeiger Human Telomerase Reverse Transcriptase (hTERT) Gene Expression in Thyroid Neoplasms Clin. Cancer Res., June 1, 1999; 5(6): 1483 - 1489. [Abstract] [Full Text] [PDF] |
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