Nucleic Acids Research, Vol 25, Issue 14 2752-2758, Copyright © 1997 by Oxford University Press
B Bailleul, I Akerblom and AD Strosberg
The leptin receptor (OB-R) is a single membrane- spanning protein that
mediates the weight-regulatory effects of leptin (OB protein). Several mRNA
splice variants have been described which either encode OB-R proteins with
cytoplasmic domains of different length or the OB-R and B219/OBR variants,
which have different 5'-untranslated regions. Here we report evidence for
the synthesis of a human mRNA splice variant of the OB-R gene that
potentially encodes a novel protein, leptin receptor gene-related protein
(OB-RGRP), which displays no sequence similarity to the leptin receptor
itself. This OB-RGRP transcript contains the first two OB-R gene
5'-untranslated exons, but then is alternatively spliced to two novel exons
which were mapped to a yeast artificial chromosome containing the leptin
receptor gene. First identified by analysis of a large human expressed
sequence tag database, the OB-RGRP transcript has now also been found in
human and mouse tissues by the use of PCR. Preliminary experiments suggest
that OB-RGRP and the OB-R variants share similar patterns of expression
that are distinct from that of the B219/OBR variant. OB-RGRP is highly
homologous to putative open reading frames in both yeast and Caenorhabditis
elegans , suggesting a phylogenetically conserved role for this novel
protein.
ARTICLES
The leptin receptor promoter controls expression of a second distinct protein
Institut Cochin de Genetique Moleculaire, Laboratoire d'ImmunoPharmacologie Moleculaire, CNRS UPR 0415, 22 rue Mechain, 75014 Paris, France. bailleul@icgm.cochin.inserm.fr
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