Nucleic Acids Research, Vol 25, Issue 15 3051-3058, Copyright © 1997 by Oxford University Press
GM Coviello-McLaughlin and KR Prowse
Telomere shortening has been causally implicated in replicative senescence
in humans. To examine the relationship between telomere length and ageing
in mice, we have utilized Mus spretus as a model species because it has
telomere lengths of approximately the same length as humans. Telomere
length and telomerase were analyzed from liver, kidney, spleen, brain and
testis from >180 M.spretus male and female mice of different ages.
Although telomere lengths for each tissue were heterogeneous, significant
changes in telomere lengths were found in spleen and brain, but not in
liver, testis or kidney. Telomerase activity was abundant in liver and
testis, but weak to non- detectable in spleen, kidney and brain. Gender
differences in mean terminal restriction fragment length were discovered in
tissues from M.spretus and from M.spretus xC57BL/6 F1 mice, in which a M.
spretus - sized telomeric smear could be measured. The comparison of the
rank order of tissue telomere lengths within individual M. spretus showed
that certain tissues tended to be longer than the others, and this ranking
also extended to tissues of the M.spretus xC57BL/6 F1 mice. These data
suggest that telomere lengths within individual tissues are regulated
independently and are genetically controlled.
ARTICLES
Telomere length regulation during postnatal development and ageing in Mus spretus
Geron Corporation, 200 Constitution Drive, Menlo Park, CA 94025, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Flores, A. Canela, E. Vera, A. Tejera, G. Cotsarelis, and M. A. Blasco The longest telomeres: a general signature of adult stem cell compartments Genes & Dev., March 1, 2008; 22(5): 654 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bermejo-Alvarez, D. Rizos, D. Rath, P. Lonergan, and A. Gutierrez-Adan Epigenetic differences between male and female bovine blastocysts produced in vitro Physiol Genomics, January 17, 2008; 32(2): 264 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Fuster and V. Andres Telomere Biology and Cardiovascular Disease Circ. Res., November 24, 2006; 99(11): 1167 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Edo and V. Andres Aging, telomeres, and atherosclerosis Cardiovasc Res, May 1, 2005; 66(2): 213 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Sato, C Maesawa, K Fujisawa, K Wada, K Oikawa, Y Takikawa, K Suzuki, H Oikawa, K Ishikawa, and T Masuda Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis Gut, July 1, 2004; 53(7): 1001 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jiang, D. B. Carter, J. Xu, X. Yang, R. S. Prather, and X. C. Tian Telomere Lengths in Cloned Transgenic Pigs Biol Reprod, June 1, 2004; 70(6): 1589 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Serrano and V. Andres Telomeres and Cardiovascular Disease: Does Size Matter? Circ. Res., March 19, 2004; 94(5): 575 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cherif, J. L. Tarry, S. E. Ozanne, and C. N. Hales Ageing and telomeres: a study into organ- and gender-specific telomere shortening Nucleic Acids Res., March 1, 2003; 31(5): 1576 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miyashita, K. Shiga, M. Yonai, K. Kaneyama, S. Kobayashi, T. Kojima, Y. Goto, M. Kishi, H. Aso, T. Suzuki, et al. Remarkable Differences in Telomere Lengths among Cloned Cattle Derived from Different Cell Types Biol Reprod, June 1, 2002; 66(6): 1649 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gilley, H. Tanaka, M. P. Hande, A. Kurimasa, G. C. Li, M. Oshimura, and D. J. Chen DNA-PKcs is critical for telomere capping PNAS, December 13, 2001; (2001) 261574698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Betts, V. Bordignon, J. R. Hill, Q. Winger, M. E. Westhusin, L. C. Smith, and W. A. King Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle PNAS, January 10, 2001; (2001) 31559298. [Abstract] [Full Text]
|
|
|
|
|
|
M. T. Hemann and C. W. Greider Wild-derived inbred mouse strains have short telomeres Nucleic Acids Res., November 15, 2000; 28(22): 4474 - 4478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Achi, N. Ravindranath, and M. Dym Telomere Length in Male Germ Cells Is Inversely Correlated with Telomerase Activity Biol Reprod, August 1, 2000; 63(2): 591 - 598. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. MELK, V. RAMASSAR, L. M. H. HELMS, R. MOORE, D. RAYNER, K. SOLEZ, and P. F. HALLORAN Telomere Shortening in Kidneys with Age J. Am. Soc. Nephrol., March 1, 2000; 11(3): 444 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Venkatesan and C. Price Telomerase expression in chickens: Constitutive activity in somatic tissues and down-regulation in culture PNAS, December 8, 1998; 95(25): 14763 - 14768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Sedivy Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells PNAS, August 4, 1998; 95(16): 9078 - 9081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhu, K. S. Hathcock, P. Hande, P. M. Lansdorp, M. F. Seldin, and R. J. Hodes Telomere length regulation in mice is linked to a novel chromosome locus PNAS, July 21, 1998; 95(15): 8648 - 8653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Betts, V. Bordignon, J. R. Hill, Q. Winger, M. E. Westhusin, L. C. Smith, and W. A. King Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle PNAS, January 30, 2001; 98(3): 1077 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gilley, H. Tanaka, M. P. Hande, A. Kurimasa, G. C. Li, M. Oshimura, and D. J. Chen DNA-PKcs is critical for telomere capping PNAS, December 18, 2001; 98(26): 15084 - 15088. [Abstract] [Full Text] [PDF]
|
|