Nucleic Acids Research, Vol 25, Issue 16 3228-3234, Copyright © 1997 by Oxford University Press
D Michel, G Chatelain, C Mauduit, M Benahmed and G Brun
Contrary to the membrane-anchored leukemia inhibitory factor receptor
(LIFR), the mouse soluble LIFR is an inhibitor of LIF action, possibly
through a ligand titration effect. Two mRNA species encoding the soluble
LIFR have been identified. Since the 3'-untranslated end of the shorter
form was shown to contain a B2 element, we have examined the possibility
that this SINE may be responsible for LIFR mRNA truncation. Transient
expression assays, using B2-derived or intron-derived sequences
independently or in conjunction, show that the B2 element has fortuitously
unmasked a cryptic pre-mRNA 3'processing activity of silent intron
sequences. The corresponding locus of the rat genome has been isolated and
was shown to be devoid of any retroposon, which may explain why no soluble
LIFR has yet been identified in any other species and further indicates
that the B2 insertion event in the mouse LIFR gene has occurred recently
during evolution. And yet, a tight tissue-specific regulation of
alternative synthesis of soluble and membrane-bound LIFR mRNA has already
emerged in mice. These results provide striking evidence for the rapid
influence of retroposition on genome expression.
ARTICLES
Recent evolutionary acquisition of alternative pre-mRNA splicing and 3' processing regulations induced by intronic B2 SINE insertion
Laboratoire de Biologie Moleculaire et Cellulaire, UMR49 CNRS-Ecole Normale Superieure de Lyon, 46 Allee d'Italie, 69364 Lyon cedex 07, France. denis.michel@univ-rennes1.fr
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